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List of substances for condition Group: Dementia

All Human Animal Risk/Association ReviewRows: 497

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Curcumin 📋✍⛔40491365Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease
Ginsenosides 📋✍⛔40510292Ginsenoside C-K inhibits A? oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions
Melatonin 📋✍⛔40518038Melatonin protects dopaminergic neurons in paraquat-induced Parkinson in rats through PI3K/AKT/Nrf2 pathway
Ginkgo Biloba 📋✍⛔40575774Proanthocyanidins from Ginkgo extract EGb 761® improve bioenergetics and stimulate neurite outgrowth in vitro
Resveratrol 📋✍⛔40507855Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer's Disease
Cannabidiol 📋✍⛔40431038Chemical Profiling of Polyphenolic Fraction of Cannabis sativa L. vr. Kompolti Industrial Inflorescences: Insights into Cannabidiol Neuroprotective Effects in a Cellular Model of Parkinson's Disease
Berberine 📋✍⛔40482960Berberine's paradox in Neurodegeneration: Therapeutic promise and safety challenges in Parkinson's disease
Quercetin 📋✍⛔40567363Neuroprotective potential of quercetin in Alzheimer's disease: targeting oxidative stress, mitochondrial dysfunction, and amyloid-? aggregation
Vitamin D3 📋✍⛔39821175Integrating network pharmacology with molecular docking and dynamics to uncover therapeutic targets and signaling mechanisms of vitamin D3 in Parkinson's disease
EGCG 📋✍⛔40172817Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells
Astaxanthin 📋✍⛔40582771Astaxanthin as an adjunct therapy in Alzheimer's disease and multiple sclerosis: neuroprotective mechanisms and future perspective
Baicalein 📋✍⛔40490169Therapeutic potential of flavonoids against ?-synuclein aggregation in Parkinson's Disease: Integrative in silico and in vitro analysis
CoQ10 📋✍⛔40277120The Potential of Coenzyme Q10 in Alzheimer's Disease: Reducing IL-17 Induced Inflammation and Oxidative Stress for Neuroprotection
Phytochemicals 📋 40114707Therapeutic potential and microRNA regulating properties of phytochemicals in Alzheimer's disease
Salidroside 📋 39503755Synthesizing network pharmacology, bioinformatics, and in vitro experimental verification to screen candidate targets of Salidroside for mitigating Alzheimer's disease
Luteolin 📋✍⛔40541584Untargeted metabolomics reveals the mechanisms of luteolin and exercise combination treatment against cognitive impairments in AD mice through modulating autophagy
Metformin 📋✍⛔40478515Low-Dose Intranasal Metformin Exerts Neuroprotective Effects in a Rat Model of Sporadic Alzheimer's Disease
Vitamin E 📋✍⛔40562949Positive effects of HIIT and vitamin E on cognitive function, angiogenesis and NRF2 antioxidant pathway in male rats with Alzheimer's disease
Ginseng 📋✍⛔40453349Korean black ginseng extract alleviates Alzheimer's disease-related cognitive impairment by activating the Nrf2/HO-1 pathway and suppressing the p38 MAPK/NF-?B/STAT3 pathways and NLRP3 inflammasome via TLR2 and TLR4 modulation
Lipoic Acid 📋✍⛔40233449? -Lipoic acid alleviates Parkinson's disease by suppressing S100A9-mediated pyroptosis
Astragalosides 📋✍⛔40449268Astragaloside IV ameliorates Parkinson's disease by inhibiting TLR4/NF-?B-dependent neuroinflammation
Food 📋 40361641Could a Mediterranean Diet Modulate Alzheimer's Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration
Docosahexaenoic Acid 📋✍⛔40316879Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer's Disease: PAD4 Inhibition and Autophagy Stimulation
Vitamin C 📋✍⛔40415164Association of antioxidants intake in diet and supplements with risk of Alzheimer's disease: a systematic review and dose-response meta-analysis of prospective cohort studies
Ginkgolides 📋 40522419A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells
Medicinal Plants 📋 40034353Synergistic activity of nootropic herbs as potent therapeutics for Alzheimer's disease: A cheminformatics, pharmacokinetics, and system pharmacology approach
Micronutrients 📋 ⛔40573071Nutrient-Wide Association Study for Dementia Risks: A Prospective Cohort Study in Middle-Aged and Older Adults
Puerarin 📋✍⛔39545064Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer's disease
Schisandra 📋✍⛔40088743Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway
Genistein 📋✍⛔39422955Genistein, A Phytoestrogen, Delays the Transition to Dementia in Prodromal Alzheimer's Disease Patients
Omega-3 Fatty Acids 📋✍⛔40563811Sleep Deprivation and Alzheimer's Disease: A Review of the Bidirectional Interactions and Therapeutic Potential of Omega-3
Crocin 📋✍⛔40419073Crocin drives intestinal microbiota variation in a rat model of Alzheimer's disease by reducing DKK3 expression
Ferulic Acid 📋✍⛔40522419A Cross-sectional In Vitro Study on the Synergistic Neuroprotective Effects of Phytochemicals Ferulic Acid and Ginkgolide B against Amyloid Beta-induced Oxidative Stress and Modulation of Multifunctional Enzyme APE1/Ref-1 in Human Neuroblastoma SH-SY5Y Cells
Icariin 📋✍ 40403897Icariin alleviates cognitive dysfunction by reducing neuroinflammation via the cGAS-STING pathway
Sulforaphane 📋✍⛔39551165Sulforaphane suppresses Aβ accumulation and tau hyperphosphorylation in vascular cognitive impairment(VCI)
Ellagic Acid 📋✍⛔39859559Ellagic Acid: A Green Multi-Target Weapon That Reduces Oxidative Stress and Inflammation to Prevent and Improve the Condition of Alzheimer's Disease
Gotu Kola 📋✍⛔40034352Centella asiatica improves cognitive function and alters the hippocampal metabolome of aged Tg2576 and wild-type mice
Nobiletin 📋✍ 40563018Possible Mitigating Effect of Nobiletin on Rotenone-Induced Parkinsonism in Male Albino Rat Model: Targeting Bmal1/Nrf2 Mediated Ferroptosis and Restoring Mitochondrial Mitophagy
Acetyl-L-Carnitine 📋✍⛔39716786Acetyl-L-Carnitine Aids in Preservation of Cholinergic Neurons and Memory in the Drosophila melanogaster Model of Alzheimer's Disease
Caffeine 📋✍⛔40255824Association Between Caffeine Intake and Alzheimer's Disease Progression: A Systematic Review
Naringenin 📋✍⛔40486726Promising neuroprotective potential of naringenin against trimethyltin-induced cognitive deficits and hippocampal neurodegeneration in rats
Vitamin B12 📋✍⛔39209095Management of Alzheimer's disease and related neurotoxic pathologies: Role of thiamine, pyridoxine and cobalamin
Fisetin 📋✍⛔40215814Single-nucleus RNA sequencing and network pharmacology reveal the mediation of fisetin on neuroinflammation in Alzheimer's disease
Lycopene 📋✍⛔40378674Lycopene alleviates cognitive dysfunctions in an Alzheimer's disease rat model via suppressing the oxidative and neuroinflammatory signaling
Hesperidin 📋✍⛔40445481Neuroprotective Effects of Hesperidin and CK2 Inhibitor DRB on A?1-42-Induced Neurotoxicity in Differentiated SH-SY5Y Cells
Probiotics 📋✍⛔40444050Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice
Saffron 📋✍⛔34224829Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models
Ashwagandha 📋✍⛔40508211Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease
Carvacrol 📋✍⛔40465192Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease
Antioxidants 📋 ⛔40330594Reduced composite dietary antioxidant index increases the risk of Parkinson's disease and all-cause mortality in Parkinson's disease patients: evidence from the NHANES database
Apigenin 📋✍⛔40215824Apigenin enhances Nrf2-induced chaperone-mediated autophagy and mitigates α-synuclein pathology: Implications for Parkinson's disease therapy
Citicoline 📋✍⛔38905051Citicoline: A Cholinergic Precursor with a Pivotal Role in Dementia and Alzheimer's Disease
Coconut Oil 📋 ⛔38052316Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats
Coffee 📋✍⛔39772974A longitudinal cohort study demonstrating the beneficial effect of moderate consumption of green tea and coffee on the prevention of dementia: The JPHC Saku Mental Health Study
Reishi Mushrooms 📋✍⛔40227285Polysaccharides from Ganoderma lucidum attenuate cognitive impairment in 5xFAD mice by inhibiting oxidative stress and modulating mitochondrial dynamics via the Nrf2/antioxidative axis activation
Selenium 📋✍⛔40341407The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review)
TUDCA 📋✍⛔39891787The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence
Vitamin B9 📋✍⛔38700503Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials
Andrographolide 📋 37239873Neuroprotection of Andrographolide against Neurotoxin MPP+-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities
Goji Berry 📋✍⛔40007341Lycium barbarum extract improves brain and visual functions in mice models of Alzheimer's disease through activating WNT pathway
Rosmarinic Acid 📋✍ 40183159Proteomic Analysis of Substantia Nigra Reveals Molecular Insights Into the Neuroprotection Effect of Rosmarinic Acid Treatment in MPTP-Induced Mouse Model of Parkinson's Disease
Thymoquinone 📋 ⛔40305274Evaluation of the Effects of Thymoquinone on RAGE/NOX4 Expressions and Brain Tissue Morphometry in Experimental Alzheimer's Disease Induced by Amyloid Beta 1-42 Peptide
Benfotiamine 📋✍⛔40176579Evaluation of neuroprotective role of benfotiamine in Alzheimer's disease model: A randomized control study
Fucoidan 📋✍⛔39521225Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis
NMN 📋✍⛔39422945Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach
Rutin 📋✍⛔40510902Potential of rutin from Rhizophora mucronata leaves as a Inhibitor of Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2 related factor 2 Keap1/Nrf2): An in silico study for Alzheimer's therapy
Cinnamon 📋✍⛔37275760Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats
Flavonoids 📋 ⛔40426656The Role of Selected Flavonoids in Modulating Neuroinflammation in Alzheimer's Disease: Mechanisms and Therapeutic Potential
Naringin 📋✍⛔39347923Naringin and Naringenin: Potential Multi-Target Agents for Alzheimer's Disease
Polyphenols 📋 40456409Polyphenol intake and risk for dementia and cognitive decline in the elderly population of Greece: A principal component analysis approach
Urolithins 📋 40280244Urolithin improves α-synuclein aggregation and DNMT1 expression in rotenone model of Parkinson's disease
Bacopa Monnieri 📋✍⛔40251199Bacopa monnieri phytochemicals as promising BACE1 inhibitors for Alzheimer's disease therapy
Mangiferin 📋 ⛔40271493Natural polyphenol mangiferin delays neuronal cell senescence by inhibiting neuroinflammation mediated by microglial activation
Piperine 📋✍⛔38158101Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats
Dihydromyricetin 📋✍⛔37712262[Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy]
Irisin 📋 40560607Correlation Between Irisin and Cognitive Functions in Alzheimer Dementia
Nicotinamide Riboside 📋✍⛔39422945Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach
Olive Oil 📋✍⛔38848192The Anti-Neuroinflammatory Effect of Extra-Virgin Olive Oil in the Triple Transgenic Mouse Model of Alzheimer's Disease
Salvianolic Acid 📋 40377822Salvianolic acid B ameliorates A?42 toxicity in A?42-expressing Drosophila model: behavioral and transcriptomic profiling
Silibinin 📋✍ 39833635Silibinin's role in counteracting neuronal apoptosis and synaptic dysfunction in Alzheimer's disease models
Asiatic Acid 📋 40005058Oral Asiatic Acid Improves Cognitive Function and Modulates Antioxidant and Mitochondrial Pathways in Female 5xFAD Mice
Boswellic Acid 📋✍⛔37248896Boswellic Acids Improve Clinical Cognitive Scores and Reduce Systemic Inflammation in Patients with Mild to Moderate Alzheimer's Disease
L-Theanine 📋✍⛔40504752Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice
Myricetin 📋 ⛔40383467Mechanism of flavonoid myricetin modulated aggregation in ?-Synuclein and its familial mutants E46K and A30P
N-Acetyl Cysteine 📋✍⛔40510771Current trends and future prospects of N-acetylcysteine utilizations in Parkinson's disease: A literature network analysis
Oleuropein 📋 36774383Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway
Paeoniflorin 📋 39884492Paeoniflorin inhibits pyruvate dehydrogenase kinase 3 and promotes BDNF activity by modulating neuronal activity and TNF-α
Pomegranate 📋 ⛔39519499In Vitro Assessment of the Neuroprotective Effects of Pomegranate (Punica granatum L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress
Pterostilbene 📋✍⛔40291020Pterostilbene: A natural neuroprotective stilbene with anti-Alzheimer's disease properties
Tea 📋 39256489Association between coffee and tea consumption and the risk of dementia in individuals with hypertension: a prospective cohort study
Anthocyanins 📋✍⛔37346934Attenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells
Baicalin 📋✍⛔39136404Proteomic analysis of baicalin intervention on protein expression and modification in the hippocampus of Alzheimer's disease model rat
Carotenoids 📋✍⛔39455919The relationship between micronutrients and cognitive ability in an elderly population with mild cognitive impairment and Alzheimer's disease: a cross-sectional study
Chlorogenic Acid 📋✍⛔40243772Neuroprotective Effects of Cilomilast and Chlorogenic Acid Against Scopolamine-Induced Memory Deficits via Modulation of the cAMP/PKA-CREB-BDNF Pathway
Chrysin 📋✍⛔39748776Therapeutic potential of chrysin in regulation of interleukin-17 signaling in a repeated intranasal amyloid-beta-induced Alzheimer's disease model
Echinacoside 📋 38000105Echinacoside exerts neuroprotection via suppressing microglial α-synuclein/TLR2/NF-κB/NLRP3 axis in parkinsonian models
Fish Oil 📋✍⛔39273347The Impact of High-Dose Fish Oil Supplementation on Mfsd2a, Aqp4, and Amyloid-β Expression in Retinal Blood Vessels of 5xFAD Alzheimer's Mouse Model
Fucoxanthin 📋✍⛔40272460Long-term fucoxanthin treatment prevents cognitive impairments and neuroinflammation via the inhibition of Nogo-A in APP/PS1 transgenic mice
Gallic Acid 📋 ⛔39909215Quantification of amyloid-β aggregation inhibitors gallic acid and rosmarinic acid in biological samples by LC-MS/MS
Grape Seed extract 📋✍⛔39682936Exploring the Neuroprotective Effects of Grape Seed Procyanidins on Amyloid-β-Induced Toxicity in Caenorhabditis elegans
Licorice Root 📋✍⛔39757620Neuroactive Phytoconstituents of Glycyrrhiza glabra for the Treatment of Alzheimer's Disease
Rapamycin 📋✍ 38640155Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies
Schisandrins 📋 40382817Schisandrin B ameliorates Alzheimer's disease by suppressing neuronal ferroptosis and ensuing microglia M1 polarization
Walnut 📋 ⛔39683877Characterization of Walnut Oil and Evaluation of Its Neuroprotective Effects in an In Vitro Model of Parkinson's Disease
Zinc 📋✍⛔40491365Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease
Emodin 📋 ⛔40340509Emodin ameliorates dopaminergic neuron loss in the MPP+ induced parkinson's disease model: significant inhibition of ferroptosis by activating UQCRC1 protein
Ganoderic Acid 📋 40054827The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway
Green Tea 📋✍⛔40561856Green tea consumption and dementia risk in community-dwelling Japanese people aged 40-74 years: A 12-year cohort study
Hydroxytyrosol 📋 37834398The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease
Icaritin 📋 39931983The Role and Molecular Mechanism of Icaritin in the Treatment of Alzheimer's Disease
Prebiotics 📋✍⛔40444050Chronic administration of prebiotics and probiotics prevent pathophysiological hallmarks of Alzheimer's disease in the cortex of APP/PS1 mice
Thymol 📋✍⛔36808768Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model
Allicin 📋✍⛔35805955Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease
Asiaticoside 📋 38471370Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation
Catalpol 📋 39545064Combined administration of catalpol, puerarin, gastrodin, and borneol modulates the Tlr4/Myd88/NF-κB signaling pathway and alleviates microglia inflammation in Alzheimer's disease
Cocoa 📋✍⛔40158278Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson's disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3?/CREB/BDNF and Apoptotic Pathways
Cordycepin 📋 40103703Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in A?1-42-induced neuronal cell models
Eicosapentaenoic Acid 📋✍⛔39490923Differential impact of eicosapentaenoic acid and docosahexaenoic acid in an animal model of Alzheimer's disease
Folate 📋✍⛔37735121Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis
Formononetin 📋 40377696Protective effect of formononetin in chronic unpredictable stress (CUS) linked to parkinson disease
Garlic 📋✍⛔40324650Preventive effect of a garlic compound on astrocyte-mediated neuroinflammation in Parkinson's disease
Green Tea Polyphenols 📋✍⛔38136170Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia
Hesperetin 📋 38517352Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids
Honokiol 📋 40481059Inhibition of levodopa metabolism to dopamine by honokiol short-chain fatty acid derivatives may enhance therapeutic efficacy in Parkinson's disease
Ligustilide 📋 36017237Ligustilide Improves Cognitive Impairment via Regulating the SIRT1/IRE1 α/XBP1s/CHOP Pathway in Vascular Dementia Rats
Lutein 📋✍⛔39337316Zeaxanthin and Lutein Ameliorate Alzheimer's Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model
Magnesium 📋✍⛔36478774Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study
Moringa Oleifera 📋✍⛔39006971Moringa oleifera leaf extract suppresses TIMM23 and NDUFS3 expression and alleviates oxidative stress induced by Aβ1-42 in neuronal cells via activation of Akt
Spikenard 📋✍⛔40358168Nardostachys jatamansi Extract and Nardosinone Exert Neuroprotective Effects by Suppressing Glucose Metabolic Reprogramming and Modulating T Cell Infiltration
Taurine 📋✍⛔39674372Taurine, an essential amino acid, attenuates rotenone-induced Parkinson's disease in rats by inhibiting alpha-synuclein aggregation and augmenting dopamine release
Bee Propolis 📋✍⛔40333577Nature's Remedies: Exploring the Potential of Propolis to Alleviate Non-Motor Manifestations of Parkinson's Disease
Beta-Carotene 📋✍⛔36982248β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure
Betaine 📋✍⛔40530574Betaine protects cerebral microvascular endothelium and ameliorates hypertension-induced cognitive dysfunction via upregulation of the endothelial nitric oxide synthase/nitric monoxide signaling pathway
Bilobalide 📋 36037147Targeting the differentiation of astrocytes by Bilobalide in the treatment of Parkinson's disease model
Choline 📋✍⛔40447055Dietary Choline Intake and Risk of Alzheimer's Dementia in Older Adults
Crocetin 📋 38764638ADME/PK Insights of Crocetin: A Molecule Having an Unusual Chemical Structure with Druglike Features
Dihydroquercetin 📋 38723817Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation
Galangin 📋 40256391Galangin reduces MPTP-induced dopamine neuron injury via the autophagy dependent-PI3K/AKT pathway
Geniposide 📋 38762146Geniposide effectively safeguards HT22 cells against Aβ-induced damage by activating mitophagy via the PINK1/Parkin signaling pathway
Ginger 📋✍⛔39829385Ginger leaf polyphenols mitigate β-amyloid toxicity via JNK/FOXO pathway activation in Caenorhabditis elegans
Hyperoside 📋 39489478Pharmacological activities and therapeutic potential of Hyperoside in the treatment of Alzheimer's and Parkinson's diseases: A systemic review
Kaempferol 📋✍⛔40002477Epigallocatechin-3-Gallate, Quercetin, and Kaempferol for Treatment of Parkinson's Disease Through Prevention of Gut Dysbiosis and Attenuation of Multiple Molecular Mechanisms of Pathogenesis
L-Carnosine 📋✍⛔39933073Carnosine Mitigates Cognitive Impairment and Dopamine Release in an Okadaic Acid-Induced Zebrafish Model with Alzheimer's Disease-like Symptoms
Panax Notoginseng 📋✍⛔40582722Total Saponins of Panax notoginseng Leaves Alleviate Vascular Dementia via the Gut-Brain Axis
Pine Bark 📋✍⛔36153882Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment
Punicalagin 📋✍⛔39374157Neuroprotective effects of punicalagin and/or micronized zeolite clinoptilolite on manganese-induced Parkinson's disease in a rat model: Involvement of multiple pathways
Senolytics 📋 40564120Role of Cellular Senescence in Parkinson's Disease: Potential for Disease-Modification Through Senotherapy
Skullcap 📋✍⛔38645989Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease
Spermidine 📋 40169099Spermidine attenuates microglial activation, neuroinflammation, and neuronal injury in rat model of vascular dementia
Spirulina 📋✍⛔39565401Aqueous extract of Spirulina exerts neuroprotection in an experimental model of Alzheimer sporadic disease in mice induced by Streptozotocin
Tangeretin 📋 35084179Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice
Wormwood 📋✍⛔36999542Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation
Artemisinin 📋 38056239Artemisinin protects dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in a mouse model of Parkinson's disease
Blueberry 📋✍⛔37647279Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus
Bromelain 📋✍⛔40491365Exploring the Neuroprotective Potential of Polyphenolic Compounds in Mitigating Quinolinic Acid-Induced Neurotoxicity in Alzheimer's Disease
Cinnamaldehyde 📋 39741957Cinnamaldehyde Attenuates the Expression of IBA1 and GFAP to Inhibit Glial Cell Activation and Inflammation in the MPTP-Induced Acute Parkinson's Disease Model
Frankincense 📋✍⛔38911256Frankincense: A neuronutrient to approach Parkinson's disease treatment
Gardenia 📋 ⛔38000495Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome
Isoliquiritigenin 📋 40414556Isoliquiritigenin attenuated cognitive impairment, cerebral tau phosphorylation and oxidative stress in a streptozotocin-induced mouse model of Alzheimer's disease
Linalool 📋 ⛔39199163Linalool and Geraniol Defend Neurons from Oxidative Stress, Inflammation, and Iron Accumulation in In Vitro Parkinson's Models
Lion's Mane Mushrooms 📋✍⛔39988819Hericium erinaceus: A possible future therapeutic treatment for the prevention and delayed progression of Alzheimer's disease? - A Narrative Review
Lotus 📋 ⛔38983916Exploring the therapeutic potential of Nelumbo nucifera leaf extract against amyloid-beta-induced toxicity in the Caenorhabditis elegans model of Alzheimer's disease
Magnolol 📋 39624588Magnolol acts as a neurorestorative agent in an Aβ1?42-induced mouse model of Alzheimer's disease
Morin 📋 38942085The combined effect of morin and hesperidin on memory ability and oxidative/nitrosative stress in a streptozotocin-induced rat model of Alzheimer's disease
Mulberry 📋 ⛔38612872Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays
Olive Polyphenols 📋 39482909Alzheimer's Disease May Benefit from Olive Oil Polyphenols: A Systematic Review on Preclinical Evidence Supporting the Effect of Oleocanthal on Amyloid-β Load
Ollive Leaf extract 📋✍⛔39585054The Role of Greek Olive Leaf Extract in Patients with Mild Alzheimer's Disease (the GOLDEN Study): A Randomized Controlled Clinical Trial
Peony 📋 ⛔40374370Neuroprotective Effects of Paeonia lactiflora Through the Regulation of Gut Dubosiella in an MPTP-Induced Parkinson's Disease Mouse Model
Rosemary 📋✍⛔40055645Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer's disease
Silymarin 📋✍⛔38353101Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease
Trehalose 📋 ⛔35618982Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson's disease
Ursolic Acid 📋✍⛔40551052Exploring the Potential Mechanism of Action of Ursolic Acid for Parkinson's Disease: An Integrative Network Pharmacology, Docking and Molecular Dynamics Study
Vitamin A 📋✍⛔40341393Impact of vitamin A on aged people's cognition and Alzheimer's disease progression in an animal model
Zeaxanthin 📋✍⛔39337316Zeaxanthin and Lutein Ameliorate Alzheimer's Disease-like Pathology: Modulation of Insulin Resistance, Neuroinflammation, and Acetylcholinesterase Activity in an Amyloid-β Rat Model
Aged Garlic 📋✍⛔35805955Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease
Alpha-Linolenic Acid 📋✍⛔40269665Alpha-Linolenic Acid for Mitigating Neuroinflammation and Dopaminergic Neuronal Loss in Parkinson's Disease: Insights From In Vivo and In Silico Studies
Anethole 📋 40465192Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease
Angelica 📋✍⛔35983893Medicine-food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications
Asparagus 📋 ⛔40454371Exploring the neuroprotective role of Asparagus racemosus (Shatavari) in Alzheimer's disease: mechanisms, evidence, and future directions
Balloon Flower 📋✍⛔40333841Role of Saponins from Platycodon grandiflorum in Alzheimer's Disease: DFT, Molecular Docking, and Simulation Studies in Key Enzymes
Bee Venom 📋✍⛔37317907Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model
Beta-Sitosterol 📋✍⛔39850118Dietary supplements for prevention of Alzheimer's disease: In vivo and in silico molecular docking studies
Butyrate 📋 ⛔38694925Buty and the beast: the complex role of butyrate in Parkinson's disease
Capsaicin 📋✍⛔37373321A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease
Catechins 📋 40172817Neuroprotective Effects of Catechins by Differentially Affecting the Binding of Beta-amyloid and Its Aggregates to the Target Cells
Coptis Chinensis 📋 ⛔38599826Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells
Creatine 📋✍⛔40395689Creatine monohydrate pilot in Alzheimer's: Feasibility, brain creatine, and cognition
Daidzein 📋✍⛔40359691Daidzein effectively mitigates amyloid-β-induced damage in SH-SY5Y neuroblastoma cells and C6 glioma cells
Dioscin 📋 38024855Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling
Fenugreek 📋✍⛔40125337Anti-inflammatory and antioxidant effects of fenugreek in preventing mice model of Alzheimer's disease
Gingerol 📋✍ 39982688Polypharmacology and Neuroprotective Effects of Gingerol in Alzheimer's Disease
Hawthorn 📋✍⛔36447359Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model
L-Arginine 📋✍⛔39326233L-arginine mitigates choroid plexus changes in Alzheimer's disease rat model via oxidative/inflammatory burden and behavioral modulation
L-Carnitine 📋✍⛔39674916Carnitine supplementation in progressive supranuclear palsy
Lavender Essential Oil 📋✍⛔40496446Effects of a home-based aromatherapy programme for the management of behavioural and psychological symptoms of dementia among older persons with dementia: A randomised controlled trial with process evaluation
Licochalcones 📋 39437838Licochalcone A Ameliorates Cognitive Dysfunction in an Alzheimer's Disease Model by Inhibiting Endoplasmic Reticulum Stress-Mediated Apoptosis
Mucuna Pruriens 📋✍⛔40137945Comparative efficacy of Mucuna pruriens and conventional levodopa in Parkinson's disease: a randomized controlled trial on pharmacokinetics and clinical perspectives from Asia
Nootkatone 📋 38001852Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model
PEA 📋✍⛔40313591Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer's disease
Pomegranate Peel extract 📋✍⛔27829013Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice
Red Sage 📋✍⛔40456474Proteomics based discovery of Salvia miltiorrhiza Bunge treating Parkinson's disease through the PINK1/Parkin pathway
Stigmasterol 📋 38461353Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles
Tanshinone 📋 40083386The effect of tanshinones on cognitive impairments in animal models of Alzheimer's disease: a systematic review and meta-analysis
Telmisartan 📋 ⛔39679694Computational insights in repurposing a cardiovascular drug for Alzheimer's disease: the role of aromatic amino acids in stabilizing the drug through Ï€-Ï€ stacking interaction
Tetrahydrocurcumin 📋✍ 34679727Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin: In Vitro Comparative Structure-Activity Studies
Turmeric 📋✍⛔35674299Neuroprotective potential of curcuminoids in modulating Alzheimer's Disease via multiple signaling pathways
Vitamin B1 📋✍⛔39836750Biotin mitigates the development of manganese-induced, Parkinson's disease-related neurotoxicity in Drosophila and human neurons
Vitamin B6 📋✍⛔39209095Management of Alzheimer's disease and related neurotoxic pathologies: Role of thiamine, pyridoxine and cobalamin
Vitamin K2 📋✍⛔34199021Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment
Vitamins 📋 38397800A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation
Withaferin A 📋 40573212Withaferin A Rescues Brain Network Dysfunction and Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Withanolides 📋 39721456The total withanolides from the leaves of Datura stramonium L. Improves Alzheimer's disease pathology by restraining neuroinflammation through NLRP3/IL-1β/IL1R1/TOM 1 pathway
5-HTP 📋✍⛔369187415-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson's Disease
Arctigenin 📋 38104254Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism
Astragalus Root 📋✍⛔36961195Exploring the target and molecular mechanism of Astragalus membranaceus in the treatment of vascular cognitive impairment based on network pharmacology and molecular docking
Basil 📋✍⛔35000160Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery
Black Pepper 📋✍⛔34235220The Effect of a Traditional Preparation Containing Piper nigrum L. and Bunium persicum (Boiss.) B.Fedtsch. on Immobility Stress-Induced Memory Loss in Mice
Caffeic Acid 📋✍⛔37864768Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches
Carnosic Acid 📋 36224322Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells
Chicoric Acid 📋 40123433Chicoric acid alleviates rotenone-induced motor dysfunction in mice: Targeting PI3K/AKT/caspase-3-associated apoptosis and neuroinflammation
Chokeberry 📋✍⛔34657937Metformin and cyanidin 3- O-galactoside from Aronia melanocarpa synergistically alleviate cognitive impairment in SAMP8 mice
Cornus 📋 39946185Cornus mas ameliorates AlCl3-induced Alzheimer's disease in rats with metabolic syndrome by regulating inflammation and oxidative stress
Cyanidin 📋✍ 40454491Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018
Diosmetin 📋 39323333Investigating In Silico and In Vitro Therapeutic Potential of Diosmetin as the Anti-Parkinson Agent
Diosmin 📋✍⛔39105973Diosmin ameliorates inflammation, apoptosis and activates PI3K/AKT pathway in Alzheimer's disease rats
Galangal 📋✍⛔36306920Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression
Geraniol 📋 39587789Protective effects of geraniol in a male rat model of Alzheimer's disease: A behavioral, biochemical, and histological study
Ginger extract 📋✍⛔39505806Ginger Extract Improves Cognitive Dysfunction via Modulation of Gut Microbiota-Derived Short-Chain Fatty Acids in D-Galactose/Ovariectomy-Induced Alzheimer-Like Disease
Grape 📋 ⛔36613906Protective Effects of Currants ( Vitis vinifera) on Corticolimbic Serotoninergic Alterations and Anxiety-like Comorbidity in a Rat Model of Parkinson's Disease
Haritaki 📋✍⛔35696798Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells
Holy Basil 📋✍⛔35900690Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels
Lauric Acid 📋✍ 40418323Effects of lauric acid on cognitive impairment in a scopolamine-induced Alzheimer's disease-like rat model
Mangosteen 📋✍⛔36552604Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease
Mushrooms 📋 ⛔38239014Mushroom intake and risk of incident disabling dementia: The Circulatory Risk in Communities Study (CIRCS)
Nattokinase 📋✍⛔39713256Natural serine proteases and their applications in combating amyloid formation
Neferine 📋 37921051Neferine exerts anti‑inflammatory activity in BV-2 microglial cells and protects mice with MPTP-induced Parkinson's disease by inhibiting NFκB activation
Nicotinamide 📋✍⛔39671543Phase 2A Proof-of-Concept Double-Blind, Randomized, Placebo-Controlled Trial of Nicotinamide in Early Alzheimer Disease
Nutmeg 📋✍⛔35662922Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease
Paeonol 📋 40465192Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease
Patchouli 📋✍⛔38996935The effect and mechanism of patchouli alcohol on cognitive dysfunction in AD mice induced by Aβ1-42 oligomers through AMPK/mTOR pathway
PQQ 📋✍⛔38454653Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease
St. Johns Wort 📋✍⛔38279301Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease
Stinging Nettle 📋✍⛔38387425The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats
Tannic Acid 📋✍⛔37712018A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease
Vitamin B3 📋✍⛔39091685Association between dietary niacin intake and risk of Parkinson's disease in US adults: cross-sectional analysis of survey data from NHANES 2005-2018
Acacetin 📋 36382256Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway
Acai Berry 📋✍⛔36010690Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways
Andrographis 📋✍⛔38057817Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway
Apple Vinegar 📋✍⛔39531579Inhibitory Potency of Chlorogenic Acid from Apple Cider Vinegar Against Alzheimer's Disease: Molecular Docking and Dynamics Validation
Aspirin 📋 ⛔36846997Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study
Astragalin 📋 40032030Astragalin actives autophagy and inhibits apoptosis of astrocytes in AD mice via down-regulating Fas/Fasl-VDAC1 pathway
Betulinic Acid 📋 40203997Betulinic acid protects against lipopolysaccharide and ferrous sulfate-induced oxidative stress, ferroptosis, apoptosis, and neuroinflammation signaling relevant to Parkinson's Disease
Bilberry 📋✍⛔32003387Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia
Biochanin A 📋 40012390Biochanin-A: A Potential Candidate for the Treatment of Alzheimer's Disease
Black Tea 📋✍⛔37483967Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies
Blackberry 📋 ⛔38430352Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling
Blackcurrant 📋✍⛔35790009Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice
Boric Acid 📋✍⛔37220543Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease
Calycosin 📋 36195188Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease
CAPE 📋 37313025Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease
Chaga Mushrooms 📋✍⛔40429872INO10, a Chaga Mushroom Extract, Alleviates Alzheimer's Disease-Related Pathology and Cognitive Deficits in 3xTg-AD Mice
Clove 📋 ⛔37851769Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat
Coconut 📋 ⛔29188860A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged
Cordyceps 📋✍⛔40508211Preclinical Evidence of Withania somnifera and Cordyceps spp.: Neuroprotective Properties for the Management of Alzheimer's Disease
Coriander 📋 ⛔35922685Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats
Coriander Essential Oil 📋✍⛔32785956Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity
Date 📋 ⛔36654869Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study
DHEA 📋✍⛔40002846Neuroprotective Effects of Dehydroepiandrosterone Sulphate Against A? Toxicity and Accumulation in Cellular and Animal Model of Alzheimer's Disease
Eleuthero 📋✍⛔40332373Acanthopanax Senticosus Saponins Prevent Cognitive Decline in Rats with Alzheimer's Disease
Essential Oils 📋 ⛔39921369Treatments of psychosomatic symptoms in Alzheimer's disease: a scoping review of the potential therapeutic effects of essential oils
Eugenol 📋 37348246Eugenol relieves the pathological manifestations of Alzheimer's disease in 5×FAD mice
Fo-Ti Root 📋✍⛔40051562Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer's disease
Fruits 📋 39350372Flavonoid-Rich Fruit Intake in Midlife and Late-Life and Associations with Risk of Dementia: The Framingham Heart Study
Genipin 📋 37865990Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease
Geranium 📋 39921688Pelargonium graveolens Attenuates Rotenone-Induced Parkinson's Disease in a Rat Model: Role of MAO-B Inhibition and In Silico Study
Giloy 📋✍⛔40057579Network pharmacology and metabolomics analysis of Tinospora cordifolia reveals BACE1 and MAOB as potential therapeutic targets for neuroprotection in Alzheimer's disease
Kudzu Root 📋✍⛔33433542In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway
Lemon Balm 📋✍⛔33122694Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression
Linoleic Acid 📋✍⛔35892594Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy
Liquiritigenin 📋 33965487Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease
Lychee 📋 ⛔31917277Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway
Malvidin 📋 40454491Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018
NAD 📋 34530866NAD + improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway
Parthenolide 📋 39017801The protective effect of parthenolide in an in vitro model of Parkinson's disease through its regulation of nuclear factor-kappa B and oxidative stress
Pelargonidin 📋 35694918Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study
Perilla 📋✍ 39554352Cold-pressed perilla seed oil: Investigating its protective influence on the gut-brain axis in mice with rotenone-induced Parkinson's disease
Persimmon 📋 ⛔34205542Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice
Phytoestrogens 📋 ⛔39422947Alzheimer's Disease and (Phyto) Estrogen Treatment: Modification of Effects by Age, Type of Treatment, and Duration of Use
Postbiotics 📋 39952328Bridging gap in the treatment of Alzheimer's disease via postbiotics: Current practices and future prospects
Procyanidins 📋 ⛔34770830Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP +-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease
Rosemary Essential Oil 📋✍⛔36986277Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition
Royal Jelly 📋✍⛔36809522Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress
Sage 📋✍⛔35137748Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model
Seaweeds 📋 ⛔40137277The Advancements of Marine Natural Products in the Treatment of Alzheimer's Disease: A Study Based on Cell and Animal Experiments
Shogaol 📋 400631446-Shogaol, a neuro-nutraceutical derived from ginger, alleviates motor symptoms and depression-like behaviors and modulates the release of monoamine neurotransmitters in Parkinson's disease mice
UDCA 📋✍⛔39891787The effects of ursodeoxycholic acid on Parkinson's disease, a mechanistic review of the recent evidence
Valerian Root 📋✍⛔31909290"Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease"
Vitamin B5 📋✍⛔32416962Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease
Vitamin B7 📋✍⛔39035497The protective effect of biotin supplementation and swimming training on cognitive impairment and mental symptoms in a rat model of Alzheimer's disease: A behavioral, biochemical, and histological study
Wogonin 📋✍⛔33147823Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation
Aloe-Emodin 📋 40125832Aloe-Emodin Improves Mitophagy in Alzheimer's Disease via Activating the AMPK/PGC-1α/SIRT3 Signaling Pathway
Anthocyanidins 📋 40454491Anthocyanidins Intake is Associated with Alzheimer's Disease Risk in Americans over 60 Years of Age: Data from NHANES 2007-2008, 2009-2010, and 2017-2018
Asafoetida 📋✍⛔36857494Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease
Atractylodes 📋✍⛔36164880[Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway]
Barberry 📋✍⛔36186093Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells
Beets 📋✍⛔38887650Exploring beetroot (Beta vulgaris L.) for diabetes mellitus and Alzheimer's disease dual therapy: in vitro and computational studies
Bergamot 📋✍⛔32260543Neuroprotective Effect of Bergamot Juice in 6-OHDA-Induced SH-SY5Y Cell Death, an In Vitro Model of Parkinson's Disease
Bergamot Essential Oil 📋✍⛔31284573Neuropharmacology of the Neuropsychiatric Symptoms of Dementia and Role of Pain: Essential Oil of Bergamot as a Novel Therapeutic Approach
Berries 📋 29401686Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects
Bitter Orange 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Black Ginger 📋✍⛔40063637Kaempferia parviflora extract and its methoxyflavones as potential anti-Alzheimer assessing in vitro, integrated computational approach, and in vivo impact on behaviour in scopolamine-induced amnesic mice
Cardamom 📋✍⛔39673650Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice
Cardamonin 📋 39673650Targeting Neuroinflammation and Apoptosis: Cardamonin's Cognitive Benefits in Alzheimer's 5XFAD Mice
Cinnamic Acid 📋 33662757A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Conjugated Linoleic Acid 📋✍⛔36028179Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels
Copper 📋✍⛔36195639Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study
Coumaric acid 📋 37414223p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model
Cranberry 📋✍⛔35631155Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease
Cryptotanshinone 📋 36124540Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model
Dihydroartemisinin 📋 39910679Therapeutic effect of dihydroartemisinin on Alzheimer's disease model mice with senile macular degeneration
Diosgenin 📋 37085711Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer's disease model mice
Escin 📋✍⛔40095493Pharmacological Evaluation of Aescin for Neuroprotection in Intracerebroventricular Streptozotocin Model of Alzheimer's Disease in Experimental Rats
Eucalyptus 📋✍⛔39486370Effect of bioactive extracts from Eucalyptus globulus leaves in experimental models of Alzheimer's disease
Eucommia 📋✍⛔40141407Identification of Key Active Constituents in Eucommia ulmoides Oliv. Leaves Against Parkinson's Disease and the Alleviative Effects via 4E-BP1 Up-Regulation
Evening Primrose Oil 📋✍⛔36464068Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism
Fermented Foods 📋 ⛔37967591Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review
Forskolin 📋✍⛔36614135Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats
Ginkgolic Acid 📋 39870805Age-related p53 SUMOylation accelerates senescence and tau pathology in Alzheimer's disease
Glucosamine 📋✍⛔37689747Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population
Glutathione 📋✍⛔35310529Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease
Glycyrrhizic Acid 📋✍⛔40346511Identifying suppressive factors of Alzheimer's disease through comprehensive analysis of real-world data: a single-center retrospective study
Hazelnut 📋 ⛔29208493Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents
Indian Gooseberry 📋 ⛔38030098Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats
Indian Mulberry 📋✍⛔36158563Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease
Isorhamnetin 📋 39560297Isorhamnetin Ameliorates Dopaminergic Neuronal Damage via Targeting FOSL1 to Activate AKT/mTOR in 6-OHDA-induced SH-SY5Y Cells
Lactobacillus plantarum 📋 ⛔38924882NMN synbiotics intervention modulates gut microbiota and metabolism in APP/PS1 Alzheimer's disease mouse models
Lavender 📋✍⛔38078339Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats
Liquiritin 📋 27589374Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β 1-42 oligomers injected into the hippocampus
Long Pepper 📋 ⛔26232071Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury
Lupeol 📋 38842663Beneficial effect of lupeol and metformin in mouse model of intracerebroventricular streptozotocin induced dementia
Mango Leaf 📋 ⛔27537110Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model
Marigold 📋✍⛔38268908Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease
Minerals 📋 40507121Actual Data on Essential Trace Elements in Parkinson's Disease
Neohesperidin 📋 38226659Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice
Nigella Sativa 📋✍⛔31016464Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats
Oleanolic Acid 📋 40537615Oleanolic acid activates the JNK-Sp1-DJ-1 axis to promote mitophagy-mediated neuroprotection in dopaminergic neurons for Parkinson's disease treatment
Onion 📋✍⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Oregano Essential Oil 📋✍⛔35201555A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats
Pistachio 📋✍⛔40384990Therapeutic Potential of Pistachio Green Hull Extract in Treating Parkinson's Disease: A Comprehensive In Vivo and In Vitro Investigation
Plum 📋 ⛔30577585Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors
Polydatin 📋✍ 40313624Polydatin attenuates Alzheimer's disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects
Progesterone 📋✍⛔36967764Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7)
Psyllium 📋✍⛔31103857Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion
Quercitrin 📋 36292931The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway
Rehmannia 📋✍⛔35784741Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease
Rose Essential Oil 📋 38688895A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats
Roselle 📋✍⛔32480228Hibiscus Sabdariffa L.: A Potent Natural Neuroprotective Agent for the Prevention of Streptozotocin-Induced Alzheimer's Disease in Mice
Safflower 📋✍⛔35940347Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model
Scutellarin 📋 39851081The synergetic effect of edaravone and scutellarin in the MPP(+)-induced cell model of Parkinson's disease
Sea Buckthorn 📋✍⛔39984555Nebulized seabuckthorn seed oil inhalation attenuates Alzheimer's disease progression in APP/PS1 mice
Serrapeptase 📋✍⛔35694981The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach
Sesamin 📋✍ 37539928Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells
Sesamol 📋 34669408Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis
Sorghum 📋 ⛔38740315The identification of active compounds and therapeutic properties of fermented and non-fermented red sorghum for the treatment of Alzheimer's dementia
Soy 📋✍⛔37677911Different types of milk consumption and the risk of dementia: Analysis from a large-scale cohort study
Soy Protein 📋✍⛔39717252Protective Effect of Whey Protein Supplement Against Rotenone Induced Motor Dysfunction in a Rat Model of Parkinson Disease
Spices 📋 34279199Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease
Strawberry 📋✍⛔33547659Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease
Syringic Acid 📋 34599991Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease
Trans-Resveratrol 📋 40362855Neuroprotective Effects of a Combination of Dietary Trans-Resveratrol and Hesperidin Against Methylglyoxal-Induced Neurotoxicity in a Depressive Amnesia Mouse Model
Tribulus Terrestris 📋✍⛔33043200Anti-Parkinson's Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β
Vitamin B Complex 📋 ⛔40158278Combining vinpocetine or cocoa with levodopa, Coenzyme Q10 and vitamin B complex mitigates rotenone-induced Parkinson's disease in rats: Impact on Nrf2/HO-1, NF-kB, AMPK/SIRT-1/Beclin-1, AKT/GSK-3?/CREB/BDNF and Apoptotic Pathways
Vitexin 📋 37102042Beneficial Role of Vitexin in Parkinson's Disease
Wine 📋 ⛔35326316Association of Alcohol Types, Coffee, and Tea Intake with Risk of Dementia: Prospective Cohort Study of UK Biobank Participants
Almond 📋 ⛔29208493Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents
Aloin 📋 35421539Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin
Alpha GPC 📋✍⛔38595916Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease
Apple 📋 ⛔26298312Effects of an Antioxidant Beverage on Biomarkers of Oxidative Stress in Alzheimer's Patients
Apricot 📋 ⛔36212969Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model
Arctiin 📋 39136502Therapeutic Effects of Arctiin on Alzheimer's Disease-like Model in Rats by Reducing Oxidative Stress, Inflammasomes and Fibrosis
Bamboo 📋✍⛔38334213The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model
Basil Essential Oil 📋✍⛔29356981Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus
Beta-Cryptoxanthin 📋 35508396Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults
Beta-Glucan 📋✍⛔36890624β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites
Beta-Lapachone 📋 30739428Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
Bitter Melon 📋✍⛔36902074The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease
Boron 📋✍⛔39515586Boron: An intriguing factor in retarding Alzheimer's progression
Buckwheat 📋 ⛔39019369Polysaccharides extracted from common buckwheat (Fagopyrum esculentum) attenuate cognitive impairment via suppressing RAGE/p38/NF-κB signaling and dysbiosis in AlCl3-treated rats
Calcium 📋✍⛔36478774Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study
Carnosol 📋 40465192Integrative Network Pharmacology, Molecular Docking, and Dynamics Simulation Guided Discovery of Anethole, Carvacrol, Carnosol, Nicotine, and Paeonol as Potential Therapeutics for Parkinson's Disease
Cashew 📋 ⛔34576912Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease
Cat's Claw 📋✍⛔17294693Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40)
Cedarwood Essential Oil 📋✍⛔32037737Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia
Celery 📋 ⛔40430359Exploring the Neuroprotective Properties of Celery (Apium graveolens Linn) Extract Against Amyloid-Beta Toxicity and Enzymes Associated with Alzheimer's Disease
Chamomile 📋✍⛔33824100Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study
Chamomile Essential Oil 📋✍⛔38229887Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease
Chebulinic Acid 📋 37453379Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses
Chlorella 📋✍⛔37144207Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease
Cinnamon Essential Oil 📋✍⛔32166553Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells
Clove Essential Oil 📋 ⛔37119836Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease
Corn Silk 📋✍⛔37563784Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation
Dandelion 📋✍⛔35053874Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo
Delphinidin 📋 40542425Delphinidin attenuates cognitive deficits and pathology of Alzheimer's disease by preventing microglial senescence via AMPK/SIRT1 pathway
Docosapentaenoic Acid 📋✍ 33178186The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models
Eclipta Alba 📋✍ 33145730Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease
Egg 📋 ⛔38782209Association of Egg Intake With Alzheimer's Dementia Risk in Older Adults: The Rush Memory and Aging Project
Elderberry 📋✍⛔28214539Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms
Equol 📋✍⛔32761299Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans
Fatty Acids 📋 34831163Medium-Chain Length Fatty Acids Enhance Aβ Degradation by Affecting Insulin-Degrading Enzyme
Fiber 📋✍⛔40589779Dietary fiber intake and hippocampal gray matter volume: an exploratory cross-sectional study in healthy adults
Fig 📋 ⛔24938828Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease
Fish 📋 ⛔33386799Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study
Fufang Danshen 📋 29770796Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease
GABA 📋✍⛔36734072The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression
Ginkgetin 📋 29214278Ginkgetin Ameliorates Neuropathological Changes in APP/PS1 Transgenical Mice Model
Glycyrrhetinic Acid 📋 3743649118β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype
Grape Seed Oil 📋 ⛔32665902Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases
Guggulsterone 📋 35714682Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway
HMB 📋✍⛔37437568Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice
Honey 📋✍⛔37570596Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids
Honeysuckle 📋 ⛔39606633Revealing the potential therapeutic mechanism of Lonicerae Japonicae Flos in Alzheimer's disease: a computational biology approach
Horny Goat Weed 📋✍⛔36051307Molecular mechanism of Epimedium in the treatment of vascular dementia based on network pharmacology and molecular docking
Hypericin 📋 37183545Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning
Isoflavones 📋✍⛔34751296Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models
Isoquercitrin 📋 34047315The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease
Jujube 📋 ⛔35922734An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways
Knotweed 📋✍⛔25856718Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1-40
Krill Oil 📋✍⛔36185487Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea-land combination to retard brain aging
L-Carnitine Tartrate 📋✍⛔36703196Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial
L-Citrulline 📋✍⛔33940559Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease
L-Glutamine 📋✍⛔38489176Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease
L-Lysine 📋✍⛔21127688Could Lysine Supplementation Prevent Alzheimer's Dementia? A Novel Hypothesis
L-Methionine 📋✍⛔34573099L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease
L-Tryptophan 📋✍⛔34105899Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway
Lemon Balm Essential Oil 📋✍⛔12143909Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa
Lemon Essential Oil 📋✍⛔33052945Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
Lettuce 📋 ⛔35101010In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa
Limonin 📋 37536186Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats
Lingonberry 📋 ⛔40076984Revealing Lingonberry's Neuroprotective Potential in Alzheimer's Disease Through Network Pharmacology and Molecular Docking
Maca Root 📋✍⛔38734297Neuroprotection of macamide in a mouse model of Alzheimer's disease involves Nrf2 signaling pathway and gut microbiota
Madecassoside 📋 32721993Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica
Magnolia 📋✍⛔38955265Neolignans in Magnolia officinalis as natural anti-Alzheimer's disease agents: A systematic review
Mandarin 📋 33808343A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes
Mustard 📋 ⛔34856751Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals
Myrtle 📋✍⛔30553998Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors
Nuts 📋 ⛔39343863Nut consumption is associated with a lower risk of all-cause dementia in adults: a community-based cohort study from the UK Biobank
Oak Acorn 📋✍⛔39408864Extraction Condition Optimization, Quantitative Analysis, and Anti-AD Bioactivity Evaluation of Acorn Polyphenols from Quercus variabilis, Quercus aliena, and Quercus dentata
Oats 📋 ⛔34684684Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice
Okra 📋 ⛔37358589Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function
Oolong Tea 📋 ⛔35629970Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice
Orange 📋 ⛔36678510Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease
Orange Essential Oil 📋✍⛔33052945Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation
Pantethine 📋✍⛔37194410Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species
Parsnip 📋 ⛔32700246Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study
Pau d'Arco 📋✍⛔35240121Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates
Pecan 📋 ⛔39929607Characterization of pecan, hickory, and walnut phospholipids and the comparable effects of pecan phospholipids with soy phospholipids on scopolamine-induced dementia in mice
Peppermint 📋✍⛔38625964Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities
Peppermint Essential Oil 📋✍⛔36986277Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition
Phloretin 📋 36463449Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk
Phosphatidylserine 📋✍⛔33163896Effects of a Nutritional Formulation Containing Caprylic and Capric Acid, Phosphatidylserine, and Docosahexaenoic Acid in Streptozotocin-Lesioned Rats
Pine Needle Essential Oil 📋✍⛔33655878Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus
Pine Nut 📋 ⛔37821052Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease
Poria Mushrooms 📋✍ 40254847Poria cocos Polysaccharide Reshapes Gut Microbiota to Regulate Short-Chain Fatty Acids and Alleviate Neuroinflammation-Related Cognitive Impairment in Alzheimer's Disease
Pregnenolone 📋✍⛔36878398Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease
Protein 📋✍⛔38674911Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60
PUFA 📋 37046127Circulating polyunsaturated fatty acids, fish oil supplementation, and risk of incident dementia: a prospective cohort study of 440,750 participants
Pumpkin Seed 📋✍⛔33759084Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism
Pyridoxal-5-Phosphate 📋✍⛔31987026An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice
Raspberry 📋✍⛔26773014Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links
Rosavin 📋 ⛔37758932Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model
Rose 📋 37078068Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study
Rosehip 📋✍⛔27563424Neuroprotective Effects of Herbal Extract (Rosa canina, Tanacetum vulgare and Urtica dioica) on Rat Model of Sporadic Alzheimer's Disease
Safranal 📋 38683404Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation
SAMe 📋✍⛔32597804S-Adenosylmethionine Alleviates Amyloid-β-Induced Neural Injury by Enhancing Trans-Sulfuration Pathway Activity in Astrocytes
Scutellarein 📋 37239029A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease
Seafood 📋 36354985Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect
Sesame 📋✍⛔37539928Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells
Sesame Oil 📋 ⛔33049345Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways
Shilajit 📋✍⛔37513872Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease
Spearmint 📋 ⛔40467024Spearmint extract Neumentix downregulates amyloid-β accumulation by promoting phagocytosis in APP23 mice
Spearmint Essential Oil 📋✍⛔31772594Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections
Star Fuit 📋 ⛔30196278Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease
Sunflower Oil 📋✍⛔39973828Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies
Sweet Potato 📋 ⛔35720655Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction
Tamarind 📋 ⛔35481086The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches
Theaflavins 📋✍ 22138428Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease
Theobromine 📋✍⛔27792010Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model
Thyme 📋✍⛔40188599Neuroprotective effect of Thymus vulgaris on paraquat induced Parkinson's disease
Thyme Essential Oil 📋 ⛔38688382Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell
Turkey Tail Mushrooms 📋 ⛔36289766Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice
Vitamin B2 📋✍⛔28775706Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine
Vitamin K 📋✍⛔35475263Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons
Vitamin K2 mk-7 📋✍ 37477796Vitamin K2 protects against aluminium chloride-mediated neurodegeneration
Vitex 📋✍⛔35023027Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol induced parkinson's disease in rat
Whey Protein 📋✍⛔37414601Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway
White Mushrooms 📋 ⛔36291298White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease
Xylitol 📋✍⛔36154609Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice