| Substance |
Info | Dose |
Warn | Link |
PubMed |
Latest article |
| Curcumin | 📋 | ✍ | ⛔ | | 38616356 | Neuroprotective and anti-inflammatory effects of curcumin in Alzheimer's disease: Targeting neuroinflammation strategies |
| Ginsenosides | 📋 | ✍ | ⛔ | | 38593704 | Total ginsenosides decrease Aβ production through activating PPARγ |
| Melatonin | 📋 | ✍ | ⛔ | | 38561619 | The Therapeutic Potential of Melatonin in Alzheimer's Disease: A Comprehensive Review |
| Ginkgo Biloba | 📋 | ✍ | ⛔ | | 38654507 | Ginkgo biloba and Its Chemical Components in the Management of Alzheimer's Disease |
| Resveratrol | 📋 | ✍ | ⛔ | | 38504306 | Unraveling the therapeutic efficacy of resveratrol in Alzheimer's disease: an umbrella review of systematic evidence |
| Cannabidiol | 📋 | ✍ | ⛔ | | 38590254 | Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis |
| Vitamin D3 | 📋 | ✍ | ⛔ | | 38532309 | Contribution of Nutritional, Lifestyle, and Metabolic Risk Factors to Parkinson's Disease |
| Berberine | 📋 | ✍ | ⛔ | | 38678955 | Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance |
| EGCG | 📋 | ✍ | ⛔ | | 38526966 | Neuroprotective effect of green tea extract (-)-epigallocatechin-3-gallate in a preformed fibril-induced mouse model of Parkinson's disease |
| Quercetin | 📋 | ✍ | ⛔ | | 38682342 | Effects of quercetin in preclinical models of Parkinson's disease: A systematic review |
| Astaxanthin | 📋 | ✍ | ⛔ | | 37929718 | Astaxanthin alleviates ganglioside metabolism disorder in the cortex of Alzheimer's disease mice |
| Baicalein | 📋 | ✍ | ⛔ | | 38460310 | Insights into dietary phytochemicals targeting Parkinson's disease key genes and pathways: A network pharmacology approach |
| Salidroside | 📋 | | | | 38424396 | Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in Parkinson's Disease |
| Ginseng | 📋 | ✍ | ⛔ | | 38707644 | Emerging evidence that ginseng components improve cognition in subjective memory impairment, mild cognitive impairment, and early Alzheimer's disease dementia |
| Lipoic Acid | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Metformin | 📋 | ✍ | ⛔ | | 38582410 | The role of the cholinergic system in the memory-protecting effects of metformin in a model of scopolamine-induced memory impairment in aged rats |
| Phytochemicals | 📋 | | | | 38471283 | Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease |
| Astragalosides | 📋 | ✍ | ⛔ | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| CoQ10 | 📋 | ✍ | ⛔ | | 38397789 | CoQ10 and Mitochondrial Dysfunction in Alzheimer's Disease |
| Luteolin | 📋 | ✍ | ⛔ | | 37943817 | Synergistic inhibition of glioblastoma multiforme through an in-silico analysis of luteolin and ferulic acid derived from Angelica sinensis and Cannabis sativa: Advancements in computational therapeutics |
| Vitamin E | 📋 | ✍ | ⛔ | | 38249609 | Dietary vitamin E intake and risk of Parkinson's disease: a cross-sectional study |
| Docosahexaenoic Acid | 📋 | ✍ | ⛔ | | 38373507 | N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma |
| Food | 📋 | | | | 38515359 | Effect of Dietary Habits on Alzheimer's Disease Progression |
| Genistein | 📋 | ✍ | ⛔ | | 38275516 | Epigallocatechin-3-Gallate and Genistein for Decreasing Gut Dysbiosis, Inhibiting Inflammasomes, and Aiding Autophagy in Alzheimer's Disease |
| Ginkgolides | 📋 | | | | 38676673 | [Ginkgolide B: mechanisms of neurobiological effects, prospects for use in the therapy of Alzheimer's disease] |
| Puerarin | 📋 | ✍ | ⛔ | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Gotu Kola | 📋 | ✍ | ⛔ | | 37440991 | Prediction of Translational Regulation by Network Interaction in Synaptic Plasticity Induced with Centella asiatica |
| Vitamin C | 📋 | ✍ | ⛔ | | 37537932 | Therapeutic Potential of Ascorbic Acid in the Management of Alzheimer's Disease: An Update |
| Acetyl-L-Carnitine | 📋 | ✍ | ⛔ | | 36988119 | A comparative study of acetyl-l-carnitine and caloric restriction impact on hippocampal autophagy, apoptosis, neurogenesis, and astroglial function in AlCl3-induced Alzheimer's in rats |
| Crocin | 📋 | ✍ | ⛔ | | 38356604 | Crocin attenuates the lipopolysaccharide-induced neuroinflammation via expression of AIM2 and NLRP1 inflammasome in an experimental model of Parkinson's disease |
| Medicinal Plants | 📋 | | | | 38419106 | A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer's disease based on the neuroinflammatory |
| Nobiletin | 📋 | ✍ | | | 37598127 | The citrus flavonoid "Nobiletin" impedes STZ-induced Alzheimer's disease in a mouse model through regulating autophagy mastered by SIRT1/FoxO3a mechanism |
| Icariin | 📋 | ✍ | | | 38412923 | Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation |
| Vitamin B12 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Caffeine | 📋 | ✍ | ⛔ | | 38513162 | Association of Coffee Consumption and Prediagnostic Caffeine Metabolites With Incident Parkinson Disease in a Population-Based Cohort |
| Ferulic Acid | 📋 | ✍ | ⛔ | | 38604452 | The neuroprotective effects of ferulic acid in toxin-induced models of Parkinson's disease: A review |
| Lycopene | 📋 | ✍ | ⛔ | | 37320982 | Lycopene destabilizes preformed Aβ fibrils: Mechanistic insights from all-atom molecular dynamics simulation |
| Omega-3 Fatty Acids | 📋 | ✍ | ⛔ | | 38678615 | Omega-3 polyunsaturated fatty acids play a protective role in a mouse model of Parkinson's disease by increasing intestinal inducible Treg cells |
| Saffron | 📋 | ✍ | ⛔ | | 34224829 | Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models |
| Schisandra | 📋 | ✍ | ⛔ | | 38565361 | Untargeted metabolomics reveals intervention effects of wine-processed Schisandra chinensis polysaccharide on Alzheimer's disease mice |
| Sulforaphane | 📋 | ✍ | ⛔ | | 37429146 | Screening of H2S donors with a red emission mitochondria-targetable fluorescent probe: Toward discovering a new therapeutic strategy for Parkinson's disease |
| Coconut Oil | 📋 | | ⛔ | | 38052316 | Coconut oil ameliorates behavioral and biochemical alterations induced by D-GAL/AlCl3 in rats |
| Ellagic Acid | 📋 | ✍ | ⛔ | | 38201915 | Ellagic Acid Prevents α-Synuclein Spread and Mitigates Toxicity by Enhancing Autophagic Flux in an Animal Model of Parkinson's Disease |
| Naringenin | 📋 | ✍ | ⛔ | | 37796415 | Naringenin, a Functional Food Component, Improves Motor and Non-Motor Symptoms in Animal Model of Parkinsonism Induced by Rotenone |
| Fisetin | 📋 | ✍ | ⛔ | | 37886009 | Evaluation of fisetin as a potential inducer of mitochondrial biogenesis in SH-SY5Y neuronal cells |
| Vitamin B9 | 📋 | ✍ | ⛔ | | 38700503 | Role of vitamin B12 and folic acid in treatment of Alzheimer's disease: a meta-analysis of randomized control trials |
| Andrographolide | 📋 | | | | 37239873 | Neuroprotection of Andrographolide against Neurotoxin MPP+-Induced Apoptosis in SH-SY5Y Cells via Activating Mitophagy, Autophagy, and Antioxidant Activities |
| Ashwagandha | 📋 | ✍ | ⛔ | | 35111460 | Withania somnifera as an Adjunctive Treatment for Refractory Restless Legs Syndrome in Parkinson's Disease: A Case Report |
| Carvacrol | 📋 | ✍ | ⛔ | | 38649135 | Neuroprotective role of Carvacrol via Nrf2/HO-1/NLRP3 axis in Rotenone-induced PD mice model |
| Micronutrients | 📋 | | ⛔ | | 38623983 | Comprehensive Insights into Pathophysiology of Alzheimer's Disease: Herbal Approaches for Mitigating Neurodegeneration |
| Citicoline | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Hesperidin | 📋 | ✍ | ⛔ | | 38423185 | Antioxidant responses driven by Hesperetin and Hesperidin counteract Parkinson's disease-like phenotypes in Drosophila melanogaster |
| TUDCA | 📋 | ✍ | ⛔ | | 38440398 | Tauroursodeoxycholic acid: a bile acid that may be used for the prevention and treatment of Alzheimer's disease |
| Cinnamon | 📋 | ✍ | ⛔ | | 37275760 | Effect of insulin and cinnamon extract on spatial memory and gene expression of GLUT1, 3, and 4 in streptozotocin-induced Alzheimer's model in rats |
| Fucoidan | 📋 | ✍ | ⛔ | | 38237671 | Fucoidan protects CA1 pyramidal neurons of the hippocampus and preserves the cognitive profile of rats subjected to transient forebrain ischemia |
| Rutin | 📋 | ✍ | ⛔ | | 38256111 | Effect of the Flavonoid Rutin on the Modulation of the Myenteric Plexuses in an Experimental Model of Parkinson's Disease |
| Selenium | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Thymoquinone | 📋 | | ⛔ | | 38660812 | Thymoquinone ameliorates symptoms of Parkinson's disease in a 6-OHDA rat model by downregulation of miR-204-3p |
| Antioxidants | 📋 | | ⛔ | | 38169888 | Current biomarkers and treatment strategies in Alzheimer disease: An overview and future perspectives |
| Apigenin | 📋 | ✍ | ⛔ | | 36646447 | A Neuroprotective Action of Quercetin and Apigenin through Inhibiting Aggregation of Aβ and Activation of TRKB Signaling in a Cellular Experiment |
| Coffee | 📋 | ✍ | ⛔ | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Naringin | 📋 | ✍ | ⛔ | | 37526460 | Pre-clinical Evidence-based Neuroprotective Potential of Naringin against Alzheimer's Disease-like Pathology: A Comprehensive Review |
| Piperine | 📋 | ✍ | ⛔ | | 38158101 | Piperine promotes PI3K/AKT/mTOR-mediated gut-brain autophagy to degrade α-Synuclein in Parkinson's disease rats |
| Probiotics | 📋 | ✍ | ⛔ | | 38510467 | Slowing Alzheimer's disease progression through probiotic supplementation |
| Dihydromyricetin | 📋 | ✍ | ⛔ | | 37712262 | [Dihydromyricetin alleviates pyroptosis and necroptosis in mice with MPTP-induced chronic Parkinson's disease by inducing autophagy] |
| Flavonoids | 📋 | | ⛔ | | 38039600 | Dietary flavonoids may have a protective and therapeutic effect in Parkinson disease: A systematic review |
| Goji Berry | 📋 | ✍ | ⛔ | | 38653878 | Lycium Barbarum Polysaccharides Improves Cognitive Functions in ICV-STZ-Induced Alzheimer's Disease Mice Model by Improving the Synaptic Structural Plasticity and Regulating IRS1/PI3K/AKT Signaling Pathway |
| Reishi Mushrooms | 📋 | ✍ | ⛔ | | 38720773 | Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease |
| Rosmarinic Acid | 📋 | ✍ | | | 36618920 | Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer's disease |
| Boswellic Acid | 📋 | ✍ | ⛔ | | 37248896 | Boswellic Acids Improve Clinical Cognitive Scores and Reduce Systemic Inflammation in Patients with Mild to Moderate Alzheimer's Disease |
| NMN | 📋 | ✍ | ⛔ | | 37812361 | The Combination of Citicoline and Nicotinamide Mononucleotide Induces Neurite Outgrowth and Mitigates Vascular Cognitive Impairment via SIRT1/CREB Pathway |
| Oleuropein | 📋 | | | | 36774383 | Oleuropein confers neuroprotection against rotenone-induced model of Parkinson's disease via BDNF/CREB/Akt pathway |
| Olive Oil | 📋 | ✍ | ⛔ | | 38709531 | Consumption of Olive Oil and Diet Quality and Risk of Dementia-Related Death |
| Silibinin | 📋 | ✍ | | | 37480498 | Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice |
| Anthocyanins | 📋 | ✍ | ⛔ | | 37346934 | Attenuation of amyloid-β-induced mitochondrial dysfunction by active components of anthocyanins in HT22 neuronal cells |
| Asiatic Acid | 📋 | | | | 32721993 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Echinacoside | 📋 | | | | 38000105 | Echinacoside exerts neuroprotection via suppressing microglial α-synuclein/TLR2/NF-κB/NLRP3 axis in parkinsonian models |
| Mangiferin | 📋 | | ⛔ | | 38142926 | Mangiferin alleviates 6-OHDA-induced Parkinson's disease by inhibiting AKR1C3 to activate Wnt signaling pathway |
| Polyphenols | 📋 | | | | 37224894 | Antiparkinsonian Effects of Polyphenols: A Narrative Review with a Focus on the Modulation of the Gut-brain Axis |
| Pomegranate | 📋 | | ⛔ | | 38074891 | A review of pomegranate supplementation: A promising remedial avenue for Alzheimer's disease |
| Rapamycin | 📋 | ✍ | | | 38640155 | Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies |
| Urolithins | 📋 | | | | 37508017 | Urolithin A in Health and Diseases: Prospects for Parkinson's Disease Management |
| Baicalin | 📋 | ✍ | ⛔ | | 38016618 | Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease |
| Fish Oil | 📋 | ✍ | ⛔ | | 38348197 | Fish oil supplementation, physical activity and risk of incident Parkinson's disease: results of longitudinal analysis from the UK Biobank |
| Fucoxanthin | 📋 | ✍ | ⛔ | | 36978877 | The Role of Fucoxanthin as a Potent Nrf2 Activator via Akt/GSK-3β/Fyn Axis against Amyloid-β Peptide-Induced Oxidative Damage |
| Gallic Acid | 📋 | | ⛔ | | 38549642 | Gallic Acid Alleviates Cognitive Impairment by Promoting Neurogenesis via the GSK3β-Nrf2 Signaling Pathway in an APP/PS1 Mouse Model |
| Grape Seed extract | 📋 | ✍ | ⛔ | | 33207644 | Effects of Grape Polyphenols on the Life Span and Neuroinflammatory Alterations Related to Neurodegenerative Parkinson Disease-Like Disturbances in Mice |
| Hydroxytyrosol | 📋 | | | | 37834398 | The Impact of Hydroxytyrosol on the Metallomic-Profile in an Animal Model of Alzheimer's Disease |
| L-Theanine | 📋 | ✍ | ⛔ | | 37191688 | L-theanine attenuates LPS-induced motor deficit in experimental rat model of Parkinson's disease: emphasis on mitochondrial activity, neuroinflammation, and neurotransmitters |
| Nicotinamide Riboside | 📋 | ✍ | ⛔ | | 38016950 | NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease |
| Pterostilbene | 📋 | ✍ | ⛔ | | 37562093 | Pterostilbene participates in TLR4- mediated inflammatory response and autophagy-dependent Aβ1-42 endocytosis in Alzheimer's disease |
| Salvianolic Acid | 📋 | | | | 37913602 | Salvianolic acid B exerts protective effects against Aβ-induced neuroinflammation through the inhibition of NLRP3 inflammasome activation and switching of M1/M2 polarization |
| Thymol | 📋 | ✍ | ⛔ | | 36808768 | Thymol in Trachyspermum ammi seed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine-induced Alzheimer's disease mouse model |
| Zinc | 📋 | ✍ | ⛔ | | 38239836 | Association of antioxidants use with the risk of dementia among community-dwelling adults in the United Kingdom biobank |
| Allicin | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Asiaticoside | 📋 | | | | 38471370 | Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation |
| Carotenoids | 📋 | ✍ | ⛔ | | 36997905 | Low blood carotenoid status in dementia and mild cognitive impairment: A systematic review and meta-analysis |
| Chrysin | 📋 | ✍ | ⛔ | | 35118868 | Anti-α-synuclein Toxicity and Anti-neurodegenerative Role of Chrysin in Transgenic Caenorhabditis elegans Models of Parkinson's Disease |
| Folate | 📋 | ✍ | ⛔ | | 37735121 | Features of Plasma Homocysteine, Vitamin B12, and Folate in Parkinson's Disease: An Updated Meta-Analysis |
| Green Tea Polyphenols | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Hesperetin | 📋 | | | | 38517352 | Natural flavonoid hesperetin blocks amyloid β-protein fibrillogenesis, depolymerizes preformed fibrils and alleviates cytotoxicity caused by amyloids |
| Licorice Root | 📋 | ✍ | ⛔ | | 35307886 | Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)-mediated neuroprotection in a rotenone-induced cellular model of Parkinson's disease by restoring the mTORC1-AMPK1 axis in autophagic regulation |
| Ligustilide | 📋 | | | | 36017237 | Ligustilide Improves Cognitive Impairment via Regulating the SIRT1/IRE1 α/XBP1s/CHOP Pathway in Vascular Dementia Rats |
| Magnesium | 📋 | ✍ | ⛔ | | 36478774 | Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study |
| Paeoniflorin | 📋 | | | | 38027768 | Network pharmacology and in vivo studies reveal the neuroprotective effects of paeoniflorin on Alzheimer's disease |
| Schisandrins | 📋 | | | | 38551405 | Effects of schisandrin B on hypoxia-related cognitive function and protein expression in vascular dementia rats |
| Walnut | 📋 | | ⛔ | | 35565661 | Walnut Oil Reduces Aβ Levels and Increases Neurite Length in a Cellular Model of Early Alzheimer Disease |
| Bacopa Monnieri | 📋 | ✍ | ⛔ | | 38143280 | Amelioration of Amyloid-β Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3β/Wnt/β-Catenin Signaling |
| Beta-Carotene | 📋 | ✍ | ⛔ | | 36982248 | β-Carotene, a Potent Amyloid Aggregation Inhibitor, Promotes Disordered Aβ Fibrillar Structure |
| Bilobalide | 📋 | | | | 36037147 | Targeting the differentiation of astrocytes by Bilobalide in the treatment of Parkinson's disease model |
| Cordycepin | 📋 | | | | 38479634 | Neuroprotective effects of cordycepin on MPTP-induced Parkinson's disease mice via suppressing PI3K/AKT/mTOR and MAPK-mediated neuroinflammation |
| Dihydroquercetin | 📋 | | | | 38723817 | Dihydroquercetin alleviates dopamine neuron loss via regulating TREM2 activation |
| Eicosapentaenoic Acid | 📋 | ✍ | ⛔ | | 38373507 | N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma |
| Green Tea | 📋 | ✍ | ⛔ | | 37483967 | Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies |
| Myricetin | 📋 | | ⛔ | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| N-Acetyl Cysteine | 📋 | ✍ | ⛔ | | 37507913 | Targeting the Cysteine Redox Proteome in Parkinson's Disease: The Role of Glutathione Precursors and Beyond |
| Pine Bark | 📋 | ✍ | ⛔ | | 36153882 | Pycnogenol® supplementation alleviates symptoms of Parkinson's disease with mild cognitive impairment |
| Skullcap | 📋 | ✍ | ⛔ | | 38645989 | Network Pharmacology and Molecular Docking Identify the Potential Mechanism and Therapeutic Role of Scutellaria baicalensis in Alzheimer's Disease |
| Tangeretin | 📋 | | | | 35084179 | Tangeretin Inhibits BACE1 Activity and Attenuates Cognitive Impairments in AD Model Mice |
| Tea | 📋 | | | | 38714417 | Coffee and tea consumption and dementia risk: The role of sex and vascular comorbidities |
| Wormwood | 📋 | ✍ | ⛔ | | 36999542 | Mechanism and Molecular Targets of a Water-Soluble Extract of Artemisia annua on the Treatment of Alzheimer's Disease Based on Network Pharmacology and Experimental Validation |
| Artemisinin | 📋 | | | | 38056239 | Artemisinin protects dopaminergic neurons against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity in a mouse model of Parkinson's disease |
| Bee Propolis | 📋 | ✍ | ⛔ | | 38583392 | Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice |
| Betaine | 📋 | ✍ | ⛔ | | 38184996 | Betaine alleviates cognitive impairment induced by homocysteine through attenuating NLRP3-mediated microglial pyroptosis in an m6A-YTHDF2-dependent manner |
| Blueberry | 📋 | ✍ | ⛔ | | 37647279 | Blueberry extracts antagonize Aβ25-35 neurotoxicity and exert a neuroprotective effect through MEK-ERK-BDNF/UCH-L1 signaling pathway in rat and mouse hippocampus |
| Crocetin | 📋 | | | | 34224829 | Saffron ameliorated motor symptoms, short life span and retinal degeneration in Parkinson's disease fly models |
| Emodin | 📋 | | ⛔ | | 38405501 | Neuroprotective, Anti-Inflammatory and Antifibrillogenic Offerings by Emodin against Alzheimer's Dementia: A Systematic Review |
| Galangin | 📋 | | | | 36834819 | Galangin Rescues Alzheimer's Amyloid-β Induced Mitophagy and Brain Organoid Growth Impairment |
| Gardenia | 📋 | | ⛔ | | 38000495 | Gardenia jasminoides J. Ellis extract attenuates memory impairment in rats with Alzheimer's disease by suppressing NLRP3 inflammasome |
| Garlic | 📋 | ✍ | ⛔ | | 36861262 | The Pharmacological Activity of Garlic ( Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential |
| Geniposide | 📋 | | | | 37451492 | Geniposide protects against neurotoxicity in mouse models of rotenone-induced Parkinson's disease involving the mTOR and Nrf2 pathways |
| Ginger | 📋 | ✍ | ⛔ | | 38397589 | Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets |
| Hyperoside | 📋 | | | | 36821955 | Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice |
| Icaritin | 📋 | | | | 37990437 | Icaritin greatly attenuates β-amyloid-induced toxicity in vivo |
| Kaempferol | 📋 | ✍ | ⛔ | | 36469163 | Kaemperfol Protects Dopaminergic Neurons by Promoting mTOR-Mediated Autophagy in Parkinson's Disease Models |
| Lutein | 📋 | ✍ | ⛔ | | 35508396 | Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults |
| Moringa Oleifera | 📋 | ✍ | ⛔ | | 36296969 | Moringa Oleifera Alleviates Aβ Burden and Improves Synaptic Plasticity and Cognitive Impairments in APP/PS1 Mice |
| Mulberry | 📋 | | ⛔ | | 38612872 | Mulberry Leaf Compounds and Gut Microbiota in Alzheimer's Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays |
| Punicalagin | 📋 | ✍ | ⛔ | | 37896179 | Punicalagin's Protective Effects on Parkinson's Progression in Socially Isolated and Socialized Rats: Insights into Multifaceted Pathway |
| Silymarin | 📋 | ✍ | ⛔ | | 38353101 | Adjunctive silymarin supplementation and its effects on disease severity, oxidative stress, and inflammation in patients with Alzheimer's disease |
| Spikenard | 📋 | ✍ | ⛔ | | 37559448 | Nardostachys jatamansi and levodopa combination alleviates Parkinson's disease symptoms in rats through activation of Nrf2 and inhibition of NLRP3 signaling pathways |
| Spirulina | 📋 | ✍ | ⛔ | | 36861852 | The effects of spirulina intake on clinical and metabolic parameters in Alzheimer's disease: A randomized, double-blind, controlled trial |
| Trehalose | 📋 | | ⛔ | | 35618982 | Trehalose ameliorates prodromal non-motor deficits and aberrant protein accumulation in a rotenone-induced mouse model of Parkinson's disease |
| Aged Garlic | 📋 | ✍ | ⛔ | | 35805955 | Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease |
| Angelica | 📋 | ✍ | ⛔ | | 35983893 | Medicine-food herb: Angelica sinensis, a potential therapeutic hope for Alzheimer's disease and related complications |
| Bee Venom | 📋 | ✍ | ⛔ | | 37317907 | Memory Enhancing and Neurogenesis Activity of Honey Bee Venom in the Symptoms of Amnesia: Using Rats with Amnesia-like Alzheimer's Disease as a Model |
| Butyrate | 📋 | | ⛔ | | 38694925 | Buty and the beast: the complex role of butyrate in Parkinson's disease |
| Capsaicin | 📋 | ✍ | ⛔ | | 37373321 | A Systematic Review of the Effects of Capsaicin on Alzheimer's Disease |
| Catalpol | 📋 | | | | 37336148 | Catalpol rescues cognitive deficits by attenuating amyloid β plaques and neuroinflammation |
| Chlorogenic Acid | 📋 | ✍ | ⛔ | | 38046466 | Aerobic exercise combined with chlorogenic acid exerts neuroprotective effects and reverses cognitive decline in Alzheimer's disease model mice (APP/PS1) via the SIRT1/ /PGC-1α/PPARγ signaling pathway |
| Choline | 📋 | ✍ | ⛔ | | 37214864 | Low circulating choline, a modifiable dietary factor, is associated with the pathological progression and metabolome dysfunction in Alzheimer's disease |
| Cinnamaldehyde | 📋 | | | | 38621979 | [Improvement effect of cinnamaldehyde on reserpine-induced Parkinson's disease rat model] |
| Cocoa | 📋 | ✍ | ⛔ | | 36009556 | Cocoa Extract Provides Protection against 6-OHDA Toxicity in SH-SY5Y Dopaminergic Neurons by Targeting PERK |
| Coptis Chinensis | 📋 | | ⛔ | | 38599826 | Protective Effects of Coptis chinensis Rhizome Extract and Its Constituents (Berberine, Coptisine, and Palmatine) against α-Synuclein Neurotoxicity in Dopaminergic SH-SY5Y Cells |
| Dioscin | 📋 | | | | 38024855 | Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling |
| Frankincense | 📋 | ✍ | ⛔ | | 35804280 | Methanolic Extract of Boswellia serrata Gum Protects the Nigral Dopaminergic Neurons from Rotenone-Induced Neurotoxicity |
| Ganoderic Acid | 📋 | | | | 37287673 | Identification of potential neuroprotective compound from Ganoderma lucidum extract targeting microtubule affinity regulation kinase 4 involved in Alzheimer's disease through molecular dynamics simulation and MMGBSA |
| Hawthorn | 📋 | ✍ | ⛔ | | 36447359 | Neuroprotective effects of hawthorn leaf flavonoids in Aβ25-35 -induced Alzheimer's disease model |
| Honokiol | 📋 | | | | 37637959 | Honokiol decreases alpha-synuclein mRNA levels and reveals novel targets for modulating alpha-synuclein expression |
| Irisin | 📋 | | | | 38658376 | Research progress on the regulatory mechanisms of Irisin on cognitive dysfunction in patients with Alzheimer's disease and the interventional role of Irisin in associated diseases |
| Linalool | 📋 | | ⛔ | | 38723901 | Linalool acts as a chemical chaperone by inhibiting amyloid-β aggregation |
| Lotus | 📋 | | ⛔ | | 36757040 | Procyanidins extracted from the lotus seedpod ameliorate cognitive impairment through CREB-BDNF pathway mediated LTP in APP/PS1 transgenic mice |
| Magnolol | 📋 | | | | 36889111 | Magnolol improves Alzheimer's disease-like pathologies and cognitive decline by promoting autophagy through activation of the AMPK/mTOR/ULK1 pathway |
| Morin | 📋 | | | | 38423257 | Protective Effects of Myricetin and Morin on Neurological Damage in Aβ1-42/Al3+ -induced Alzheimer's Disease Model of Rats |
| Nootkatone | 📋 | | | | 38001852 | Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson's Disease Mouse Model |
| Olive Polyphenols | 📋 | | | | 32486023 | Healthspan Enhancement by Olive Polyphenols in C. elegans Wild Type and Parkinson's Models |
| Ollive Leaf extract | 📋 | ✍ | ⛔ | | 38136170 | Memory Recovery Effect of a New Bioactive Innovative Combination in Rats with Experimental Dementia |
| Pomegranate Peel extract | 📋 | ✍ | ⛔ | | 27829013 | Neuroprotective Effects of Pomegranate Peel Extract after Chronic Infusion with Amyloid-β Peptide in Mice |
| Spermidine | 📋 | | | | 38401586 | Synergistic effect of spermidine and ciprofloxacin against Alzheimer's disease in male rat via ferroptosis modulation |
| Stigmasterol | 📋 | | | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Tetrahydrocurcumin | 📋 | ✍ | | | 34679727 | Tetrahydrocurcumin Has Similar Anti-Amyloid Properties as Curcumin: In Vitro Comparative Structure-Activity Studies |
| Turmeric | 📋 | ✍ | ⛔ | | 35674299 | Neuroprotective potential of curcuminoids in modulating Alzheimer's Disease via multiple signaling pathways |
| Vitamin A | 📋 | ✍ | ⛔ | | 36949616 | Reactive astrocytes targeting with oral vitamin A: Efficient neuronal regeneration for Parkinson's disease treatment and reversal of associated liver fibrosis |
| Vitamin K2 | 📋 | ✍ | ⛔ | | 34199021 | Vitamin K2 Holds Promise for Alzheimer's Prevention and Treatment |
| Vitamins | 📋 | | | | 38397800 | A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer's Disease: A Focus on Probiotic and Vitamin Co-Supplementation |
| Zeaxanthin | 📋 | ✍ | ⛔ | | 35508396 | Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults |
| 5-HTP | 📋 | ✍ | ⛔ | | 36918741 | 5-Hydroxytryptophan Reduces Levodopa-Induced Dyskinesia via Regulating AKT/mTOR/S6K and CREB/ΔFosB Signals in a Mouse Model of Parkinson's Disease |
| Alpha-Linolenic Acid | 📋 | ✍ | ⛔ | | 35006402 | α-Linolenic acid induces clearance of Tau seeds via Actin-remodeling in Microglia |
| Arctigenin | 📋 | | | | 38104254 | Arctigenin attenuated spatial memory impairment in pR5 mice by regulating mitochondrial energy metabolism |
| Asparagus | 📋 | | ⛔ | | 37650072 | Effect of a Standardized Extract of Asparagus officinalis Stem (ETAS®50) on Cognitive Function, Psychological Symptoms, and Behavior in Patients with Dementia: A Randomized Crossover Trial |
| Astragalus Root | 📋 | ✍ | ⛔ | | 36961195 | Exploring the target and molecular mechanism of Astragalus membranaceus in the treatment of vascular cognitive impairment based on network pharmacology and molecular docking |
| Basil | 📋 | ✍ | ⛔ | | 35000160 | Potential innovation against Alzheimer's disorder: a tricomponent combination of natural antioxidants (vitamin E, quercetin, and basil oil) and the development of its intranasal delivery |
| Beta-Sitosterol | 📋 | ✍ | ⛔ | | 38461353 | Deciphering the effect of phytosterols on Alzheimer's disease and Parkinson's disease: the mediating role of lipid profiles |
| Black Pepper | 📋 | ✍ | ⛔ | | 34235220 | The Effect of a Traditional Preparation Containing Piper nigrum L. and Bunium persicum (Boiss.) B.Fedtsch. on Immobility Stress-Induced Memory Loss in Mice |
| Bromelain | 📋 | ✍ | ⛔ | | 36462588 | Ameliorative effects of bromelain on aluminum-induced Alzheimer's disease in rats through modulation of TXNIP pathway |
| Caffeic Acid | 📋 | ✍ | ⛔ | | 37864768 | Implication of Caffeic Acid for the Prevention and Treatment of Alzheimer's Disease: Understanding the Binding with Human Transferrin Using In Silico and In Vitro Approaches |
| Carnosic Acid | 📋 | | | | 36224322 | Carnosic Acid Attenuates AβOs-Induced Apoptosis and Synaptic Impairment via Regulating NMDAR2B and Its Downstream Cascades in SH-SY5Y Cells |
| Chokeberry | 📋 | ✍ | ⛔ | | 34657937 | Metformin and cyanidin 3- O-galactoside from Aronia melanocarpa synergistically alleviate cognitive impairment in SAMP8 mice |
| Fenugreek | 📋 | ✍ | ⛔ | | 37231762 | Pharmacological attributes of Fenugreek with special reference to Alzheimer's disease |
| Formononetin | 📋 | | | | 35304289 | Formononetin attenuates Aβ25-35-induced adhesion molecules in HBMECs via Nrf2 activation |
| Galangal | 📋 | ✍ | ⛔ | | 36306920 | Combination of Alpinia Oxyphylla Fructus and Schisandra Chinensis Fructus Ameliorates Aluminum-induced Alzheimer's Disease via reducing BACE1 Expression |
| Gingerol | 📋 | ✍ | | | 38397589 | Screening of Active Substances Regulating Alzheimer's Disease in Ginger and Visualization of the Effectiveness on 6-Gingerol Pathway Targets |
| Grape | 📋 | | ⛔ | | 36613906 | Protective Effects of Currants ( Vitis vinifera) on Corticolimbic Serotoninergic Alterations and Anxiety-like Comorbidity in a Rat Model of Parkinson's Disease |
| Haritaki | 📋 | ✍ | ⛔ | | 35696798 | Autophagy activation by Terminalia chebula Retz. reduce Aβ generation by shifting APP processing toward non-amyloidogenic pathway in APPswe transgenic SH-SY5Y cells |
| Holy Basil | 📋 | ✍ | ⛔ | | 35900690 | Amelioration of intracerebroventricular streptozotocin-induced cognitive dysfunction by Ocimum sanctum L. through the modulation of inflammation and GLP-1 levels |
| Isoliquiritigenin | 📋 | | | | 36484427 | Isoliquiritigenin inhibits microglia-mediated neuroinflammation in models of Parkinson's disease via JNK/AKT/NFκB signaling pathway |
| L-Arginine | 📋 | ✍ | ⛔ | | 37660966 | Protective effects of L-arginine on Alzheimer's disease: Modulating hippocampal nitric oxide levels and memory deficits in aluminum chloride-induced rat model |
| L-Carnitine | 📋 | ✍ | ⛔ | | 36703196 | Combined metabolic activators improve cognitive functions in Alzheimer's disease patients: a randomised, double-blinded, placebo-controlled phase-II trial |
| L-Carnosine | 📋 | ✍ | ⛔ | | 35091983 | Swimming exercise versus L-carnosine supplementation for Alzheimer's dementia in rats: implication of circulating and hippocampal FNDC5/irisin |
| Lavender Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Licochalcones | 📋 | | | | 37762479 | Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment |
| Lion's Mane Mushrooms | 📋 | ✍ | ⛔ | | 36289766 | Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice |
| Mangosteen | 📋 | ✍ | ⛔ | | 36552604 | Mangosteen Pericarp Extract Supplementation Boosts Antioxidant Status via Rebuilding Gut Microbiota to Attenuate Motor Deficit in 6-OHDA-Induced Parkinson's Disease |
| Mushrooms | 📋 | | ⛔ | | 38239014 | Mushroom intake and risk of incident disabling dementia: The Circulatory Risk in Communities Study (CIRCS) |
| Neferine | 📋 | | | | 37921051 | Neferine exerts anti‑inflammatory activity in BV‑2 microglial cells and protects mice with MPTP‑induced Parkinson's disease by inhibiting NF‑κB activation |
| Nutmeg | 📋 | ✍ | ⛔ | | 35662922 | Inhibitory Effects of Macelignan on Tau Phosphorylation and Aβ Aggregation in the Cell Model of Alzheimer's Disease |
| Peony | 📋 | | ⛔ | | 37838295 | Total Glucosides of White Paeony Capsule ameliorates Parkinson's disease-like behavior in MPTP-induced mice model by regulating LRRK2/alpha-synuclein signaling |
| PQQ | 📋 | ✍ | ⛔ | | 38454653 | Deep Learning-Driven Exploration of Pyrroloquinoline Quinone Neuroprotective Activity in Alzheimer's Disease |
| Prebiotics | 📋 | ✍ | ⛔ | | 38495755 | Gut microbiota and its metabolites in Alzheimer's disease: from pathogenesis to treatment |
| Red Sage | 📋 | ✍ | ⛔ | | 34217797 | Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and Drosophila melanogaster model of Alzheimer's disease |
| Rosemary | 📋 | ✍ | ⛔ | | 38258779 | Deciphering Neuroprotective Effect of Rosmarinus officinalis L. (syn. Salvia rosmarinus Spenn.) through Preclinical and Clinical Studies |
| Senolytics | 📋 | | | | 37874084 | Translating the Biology of Aging into New Therapeutics for Alzheimer's Disease: Senolytics |
| St. Johns Wort | 📋 | ✍ | ⛔ | | 38279301 | Apolar Extracts of St. John's Wort Alleviate the Effects of β-Amyloid Toxicity in Early Alzheimer's Disease |
| Stinging Nettle | 📋 | ✍ | ⛔ | | 38387425 | The role of stinging nettle (Urtica dioica L.) in the management of rotenone-induced Parkinson's disease in rats |
| Tannic Acid | 📋 | ✍ | ⛔ | | 37712018 | A natural polyphenol activates and enhances GPX4 to mitigate amyloid-β induced ferroptosis in Alzheimer's disease |
| Tanshinone | 📋 | | | | 38659601 | Tanshinone IIA improves Alzheimer's disease via RNA nuclear-enriched abundant transcript 1/microRNA-291a-3p/member RAS oncogene family Rab22a axis |
| Taurine | 📋 | ✍ | ⛔ | | 38548872 | Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2 |
| Telmisartan | 📋 | | ⛔ | | 38419447 | Telmisartan Protects Mitochondrial Function, Gait, and Neuronal Apoptosis by Activating the Akt/GSK3β/PGC1α Pathway in an MPTP-Induced Mouse Model of Parkinson's Disease |
| Ursolic Acid | 📋 | ✍ | ⛔ | | 36618920 | Ursolic acid and rosmarinic acid ameliorate alterations in hippocampal neurogenesis and social memory induced by amyloid beta in mouse model of Alzheimer's disease |
| Vitamin B6 | 📋 | ✍ | ⛔ | | 32071304 | Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection |
| Withanolides | 📋 | | | | 34680087 | Effect of Ashwagandha Withanolides on Muscle Cell Differentiation |
| Acacetin | 📋 | | | | 36382256 | Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway |
| Acai Berry | 📋 | ✍ | ⛔ | | 36010690 | Açai Berry Mitigates Vascular Dementia-Induced Neuropathological Alterations Modulating Nrf-2/Beclin1 Pathways |
| Andrographis | 📋 | ✍ | ⛔ | | 38057817 | Ethanol extract of Andrographis paniculata alleviates aluminum-induced neurotoxicity and cognitive impairment through regulating the p62-keap1-Nrf2 pathway |
| Anethole | 📋 | | | | 37972114 | Anethole attenuates motor dysfunctions, striatal neuronal activity deficiency and blood brain barrier permeability by decreasing striatal α-synuclein and oxidative stress in rotenone-induced Parkinson's disease of male rats |
| Aspirin | 📋 | | ⛔ | | 36846997 | Aspirin Use and Risk of Alzheimer's Disease: A 2-Sample Mendelian Randomization Study |
| Bilberry | 📋 | ✍ | ⛔ | | 32003387 | Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia |
| Black Tea | 📋 | ✍ | ⛔ | | 37483967 | Tea intake or consumption and the risk of dementia: a meta-analysis of prospective cohort studies |
| Blackberry | 📋 | | ⛔ | | 38430352 | Treatment with Blackberry Extract and Metformin in Sporadic Alzheimer's Disease Model: Impact on Memory, Inflammation, Redox Status, Phosphorylated Tau Protein and Insulin Signaling |
| Blackcurrant | 📋 | ✍ | ⛔ | | 35790009 | Anthocyanin-rich blackcurrant extract improves long-term memory impairment and emotional abnormality in senescence-accelerated mice |
| Boric Acid | 📋 | ✍ | ⛔ | | 37220543 | Therapeutic Efficacy of Boric Acid Treatment on Brain Tissue and Cognitive Functions in Rats with Experimental Alzheimer's Disease |
| Calycosin | 📋 | | | | 36195188 | Calycosin ameliorates advanced glycation end product-induced neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease |
| CAPE | 📋 | | | | 37313025 | Caffeic Acid Phenethyl Ester With Mesenchymal Stem Cells Improves Behavioral and Histopathological Changes in the Rat Model of Parkinson Disease |
| Catechins | 📋 | | | | 35337893 | Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB, IκKB, and p53 genes in male Wistar rats |
| Chicoric Acid | 📋 | | | | 38542381 | Chicoric Acid Ameliorated Beta-Amyloid Pathology and Enhanced Expression of Synaptic-Function-Related Markers via L1CAM in Alzheimer's Disease Models |
| Clove | 📋 | | ⛔ | | 37851769 | Neuroprotective effects of a combination of Boswellia papyrifera and Syzygium aromaticum on AlCl3 induced Alzheimer's disease in male albino rat |
| Coconut | 📋 | | ⛔ | | 29188860 | A Keto-Mediet Approach with Coconut Substitution and Exercise May Delay the Onset of Alzheimer's Disease among Middle-Aged |
| Coriander | 📋 | | ⛔ | | 35922685 | Heated Leaf Extract of Coriandrum sativum L. Protects Nigral Dopaminergic Degeneration in Rats |
| Coriander Essential Oil | 📋 | ✍ | ⛔ | | 32785956 | Lavender and coriander essential oils and their main component linalool exert a protective effect against amyloid-β neurotoxicity |
| Creatine | 📋 | ✍ | ⛔ | | 38262563 | Creatine supplementation with exercise reduces α-synuclein oligomerization and necroptosis in Parkinson's disease mouse model |
| Cyanidin | 📋 | ✍ | | | 38705400 | Cyanidin improves spatial memory and cognition in bisphenol A-induced rat model of Alzheimer's-like neuropathology by restoring canonical Wnt signaling |
| Daidzein | 📋 | ✍ | ⛔ | | 38679467 | Daidzein ameliorates nonmotor symptoms of manganese-induced Parkinsonism in zebrafish model: Behavioural and biochemical approach |
| Date | 📋 | | ⛔ | | 36654869 | Effects of Phoenix dactylifera against Streptozotocin-Aluminium Chloride Induced Alzheimer's Rats and Their In Silico Study |
| Diosmetin | 📋 | | | | 35958986 | Effect of Date Palm ( Phoenix dactylifera) Phytochemicals on Aβ 1-40 Amyloid Formation: An in-silico Analysis |
| Diosmin | 📋 | ✍ | ⛔ | | 34656609 | The potential neuroprotective effect of diosmin in rotenone-induced model of Parkinson's disease in rats |
| Eugenol | 📋 | | | | 37348246 | Eugenol relieves the pathological manifestations of Alzheimer's disease in 5×FAD mice |
| Genipin | 📋 | | | | 37865990 | Genipin and pyrogallol: Two natural small molecules targeting the modulation of disordered proteins in Alzheimer's disease |
| Ginger extract | 📋 | ✍ | ⛔ | | 31057649 | WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice |
| Kudzu Root | 📋 | ✍ | ⛔ | | 33433542 | In silico-determined compound from the root of Pueraria lobate alleviates synaptic plasticity injury induced by Alzheimer's disease via the p38MAPK-CREB signaling pathway |
| Lemon Balm | 📋 | ✍ | ⛔ | | 33122694 | Safety and efficacy of Melissa officinalis extract containing rosmarinic acid in the prevention of Alzheimer's disease progression |
| Linoleic Acid | 📋 | ✍ | ⛔ | | 35892594 | Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy |
| Liquiritigenin | 📋 | | | | 33965487 | Exploring the inhibitory effects of liquiritigenin against tau fibrillation and related neurotoxicity as a model of preventive care in Alzheimer's disease |
| Lychee | 📋 | | ⛔ | | 31917277 | Polyphenols isolated from lychee seed inhibit Alzheimer's disease-associated Tau through improving insulin resistance via the IRS-1/PI3K/Akt/GSK-3β pathway |
| NAD | 📋 | | | | 34530866 | NAD + improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway |
| Nicotinamide | 📋 | ✍ | ⛔ | | 36428497 | Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson's Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways |
| Paeonol | 📋 | | | | 34997723 | Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice |
| Patchouli | 📋 | ✍ | ⛔ | | 36717922 | Patchouli alcohol attenuates the cognitive deficits in a transgenic mouse model of Alzheimer's disease via modulating neuropathology and gut microbiota through suppressing C/EBPβ/AEP pathway |
| PEA | 📋 | ✍ | ⛔ | | 34658885 | Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer's Disease |
| Pelargonidin | 📋 | | | | 35694918 | Pelargonidin and Berry Intake Association with Alzheimer's Disease Neuropathology: A Community-Based Study |
| Persimmon | 📋 | | ⛔ | | 34205542 | Immature Persimmon Suppresses Amyloid Beta (Aβ) Mediated Cognitive Dysfunction via Tau Pathology in ICR Mice |
| Procyanidins | 📋 | | ⛔ | | 34770830 | Neuroprotective Effects of B-Type Cinnamon Procyanidin Oligomers on MPP +-Induced Apoptosis in a Cell Culture Model of Parkinson's Disease |
| Rosemary Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Royal Jelly | 📋 | ✍ | ⛔ | | 36809522 | Royal jelly improves learning and memory deficits in an amyloid β-induced model of Alzheimer's disease in male rats: Involvement of oxidative stress |
| Sage | 📋 | ✍ | ⛔ | | 35137748 | Insights into the neuroprotective effects of Salvia officinalis L. and Salvia microphylla Kunth in the memory impairment rat model |
| Valerian Root | 📋 | ✍ | ⛔ | | 31909290 | "Effect of valerenic acid on neuroinflammation in a MPTP-induced mouse model of Parkinson's disease" |
| Vitamin B1 | 📋 | ✍ | ⛔ | | 36275801 | Pharmacological thiamine levels as a therapeutic approach in Alzheimer's disease |
| Vitamin B3 | 📋 | ✍ | ⛔ | | 34220485 | Niacin Enhancement for Parkinson's Disease: An Effectiveness Trial |
| Vitamin B5 | 📋 | ✍ | ⛔ | | 32416962 | Cerebral Deficiency of Vitamin B5 (D-Pantothenic Acid; Pantothenate) as a Potentially-Reversible Cause of Neurodegeneration and Dementia in Sporadic Alzheimer's Disease |
| Wogonin | 📋 | ✍ | ⛔ | | 33147823 | Neuroprotective Effects of Baicalein, Wogonin, and Oroxylin A on Amyloid Beta-Induced Toxicity via NF-κB/MAPK Pathway Modulation |
| Apple Vinegar | 📋 | ✍ | ⛔ | | 34323669 | Neuroprotective Efficacy of Apple Cider Vinegar on Zinc-High Fat Diet-Induced Mono Amine Oxidase Alteration in Murine Model of AD |
| Asafoetida | 📋 | ✍ | ⛔ | | 36857494 | Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease |
| Atractylodes | 📋 | ✍ | ⛔ | | 36164880 | [Mechanism of Atractylodes macrocephala against Alzheimer's disease via regulating lysophagy based on LKB1-AMPK-TFEB pathway] |
| Balloon Flower | 📋 | ✍ | ⛔ | | 34943071 | Crude Saponin from Platycodon grandiflorum Attenuates Aβ-Induced Neurotoxicity via Antioxidant, Anti-Inflammatory and Anti-Apoptotic Signaling Pathways |
| Barberry | 📋 | ✍ | ⛔ | | 36186093 | Neuroprotective Effect of Root Extracts of Berberis Vulgaris (Barberry) on Oxidative Stress on SH-SY5Y Cells |
| Bergamot | 📋 | ✍ | ⛔ | | 32260543 | Neuroprotective Effect of Bergamot Juice in 6-OHDA-Induced SH-SY5Y Cell Death, an In Vitro Model of Parkinson's Disease |
| Bergamot Essential Oil | 📋 | ✍ | ⛔ | | 31284573 | Neuropharmacology of the Neuropsychiatric Symptoms of Dementia and Role of Pain: Essential Oil of Bergamot as a Novel Therapeutic Approach |
| Berries | 📋 | | | | 29401686 | Evaluation of Polyphenol Anthocyanin-Enriched Extracts of Blackberry, Black Raspberry, Blueberry, Cranberry, Red Raspberry, and Strawberry for Free Radical Scavenging, Reactive Carbonyl Species Trapping, Anti-Glycation, Anti-β-Amyloid Aggregation, and Microglial Neuroprotective Effects |
| Betulinic Acid | 📋 | | | | 36474564 | The effects of betulinic acid chronic administration on the motor, non-motor behaviors, and globus pallidus local field potential power in a rat model of hemiparkinsonism |
| Bitter Orange | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Chaga Mushrooms | 📋 | ✍ | ⛔ | | 38053824 | Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system |
| Cinnamic Acid | 📋 | | | | 33662757 | A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease |
| Conjugated Linoleic Acid | 📋 | ✍ | ⛔ | | 36028179 | Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels |
| Copper | 📋 | ✍ | ⛔ | | 36195639 | Brain copper may protect from cognitive decline and Alzheimer's disease pathology: a community-based study |
| Cordyceps | 📋 | ✍ | ⛔ | | 34936310 | Caterpillar Medicinal Mushroom, Cordyceps militaris (Ascomycota), Attenuates Aβ1-42-Induced Amyloidogenesis and Inflammatory Response by Suppressing Amyloid Precursor Protein Progression and p38 MAPK/JNK Activation |
| Cornus | 📋 | | | | 37393274 | Neuroprotective effects of morroniside from Cornus officinalis sieb. Et zucc against Parkinson's disease via inhibiting oxidative stress and ferroptosis |
| Coumaric acid | 📋 | | | | 37414223 | p-Coumaric acid attenuates the effects of Aβ42 in vitro and in a Drosophila Alzheimer's disease model |
| Cranberry | 📋 | ✍ | ⛔ | | 35631155 | Neuroprotective Effects of Cranberry Juice Treatment in a Rat Model of Parkinson's Disease |
| Cryptotanshinone | 📋 | | | | 36124540 | Cryptotanshinone protects against oxidative stress in the paraquat-induced Parkinson's disease model |
| Diosgenin | 📋 | | | | 37085711 | Diosgenin restores memory function via SPARC-driven axonal growth from the hippocampus to the PFC in Alzheimer's disease model mice |
| Essential Oils | 📋 | | ⛔ | | 34141578 | Essential oils for agitation in dementia [rELOAD]: A pragmatic, cluster-randomized, placebo-controlled, pilot feasibility trial |
| Evening Primrose Oil | 📋 | ✍ | ⛔ | | 36464068 | Protective effects of evening primrose oil on behavioral activities, nigral microglia and histopathological changes in a rat model of rotenone-induced parkinsonism |
| Fermented Foods | 📋 | | ⛔ | | 37967591 | Does a pickle a day keep Alzheimer's away? Fermented food in Alzheimer's disease: A review |
| Fo-Ti Root | 📋 | ✍ | ⛔ | | 29668503 | Tetrahydroxystilbene glycoside antagonizes β-amyloid-induced inflammatory injury in microglia cells by regulating PU.1 expression |
| Forskolin | 📋 | ✍ | ⛔ | | 36614135 | Intranasal Administration of Forskolin and Noopept Reverses Parkinsonian Pathology in PINK1 Knockout Rats |
| Fruits | 📋 | | | | 38347678 | Causal association between plant foods intake and Alzheimer's disease: a Mendelian randomization study |
| Geraniol | 📋 | | | | 37054939 | Geraniol improves passive avoidance memory and hippocampal synaptic plasticity deficits in a rat model of Alzheimer's disease |
| Geranium | 📋 | | | | 37819493 | Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model |
| Giloy | 📋 | ✍ | ⛔ | | 37579290 | Neuroprotective Effects of Tinospora cordifolia via Reducing the Oxidative Stress and Mitochondrial Dysfunction against Rotenone-Induced PD Mice |
| Glucosamine | 📋 | ✍ | ⛔ | | 37689747 | Habitual glucosamine use, APOE genotypes, and risk of incident cause-specific dementia in the older population |
| Glutathione | 📋 | ✍ | ⛔ | | 35310529 | Olive polyphenols and bioavailable glutathione: Promising results in patients diagnosed with mild Alzheimer's disease |
| Hazelnut | 📋 | | ⛔ | | 29208493 | Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents |
| Indian Gooseberry | 📋 | | ⛔ | | 38030098 | Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats |
| Indian Mulberry | 📋 | ✍ | ⛔ | | 36158563 | Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease |
| Lauric Acid | 📋 | ✍ | | | 32863249 | Lauric acid: Its role in behavioral modulation, neuro-inflammatory and oxidative stress markers in haloperidol induced Parkinson's disease |
| Lavender | 📋 | ✍ | ⛔ | | 38078339 | Activity of Citrus aurantium and Lavandula angustifolia in Alzheimer's Disease Symptoms in Male Wistar Rats |
| Liquiritin | 📋 | | | | 27589374 | Neuroprotective effects of liquiritin on cognitive deficits induced by soluble amyloid-β 1-42 oligomers injected into the hippocampus |
| Long Pepper | 📋 | | ⛔ | | 26232071 | Protection effect of piperine and piperlonguminine from Piper longum L. alkaloids against rotenone-induced neuronal injury |
| Mango Leaf | 📋 | | ⛔ | | 27537110 | Mango leaf extract improves central pathology and cognitive impairment in a type 2 diabetes mouse model |
| Marigold | 📋 | ✍ | ⛔ | | 38268908 | Active compounds from Calendula officinalis flowers act via PI3K and ERK signaling pathways to offer neuroprotective effects against Parkinson's disease |
| Mucuna Pruriens | 📋 | ✍ | ⛔ | | 35630617 | Mucuna pruriens Seed Aqueous Extract Improved Neuroprotective and Acetylcholinesterase Inhibitory Effects Compared with Synthetic L-Dopa |
| Nattokinase | 📋 | ✍ | ⛔ | | 37263404 | Nattokinase prevents β-amyloid peptide (Aβ1-42) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption in mice |
| Neohesperidin | 📋 | | | | 38226659 | Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice |
| Nigella Sativa | 📋 | ✍ | ⛔ | | 31016464 | Nigella sativa and thymoquinone attenuate oxidative stress and cognitive impairment following cerebral hypoperfusion in rats |
| Onion | 📋 | ✍ | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Oregano Essential Oil | 📋 | ✍ | ⛔ | | 35201555 | A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats |
| Parthenolide | 📋 | | | | 37992573 | Parthenolide alleviates cognitive dysfunction and neurotoxicity via regulation of AMPK/GSK3β(Ser9)/Nrf2 signaling pathway |
| Perilla | 📋 | ✍ | | | 35723398 | Perilla frutescens Leaf Extract Attenuates Vascular Dementia-Associated Memory Deficits, Neuronal Damages, and Microglial Activation |
| Phytoestrogens | 📋 | | ⛔ | | 34527172 | The Beneficial Role of Natural Endocrine Disruptors: Phytoestrogens in Alzheimer's Disease |
| Plum | 📋 | | ⛔ | | 30577585 | Potential Application of Prunus armeniaca L. and P. domestica L. Leaf Essential Oils as Antioxidant and of Cholinesterases Inhibitors |
| Progesterone | 📋 | ✍ | ⛔ | | 36967764 | Progesterone exerts a neuroprotective action in a Parkinson's disease human cell model through membrane progesterone receptor α (mPRα/PAQR7) |
| Psyllium | 📋 | ✍ | ⛔ | | 31103857 | Intake of Psyllium Seed Husk Reduces White Matter Damage in a Rat Model of Chronic Cerebral Hypoperfusion |
| Quercitrin | 📋 | | | | 36292931 | The Flavonol Quercitrin Hinders GSK3 Activity and Potentiates the Wnt/β-Catenin Signaling Pathway |
| Rehmannia | 📋 | ✍ | ⛔ | | 35784741 | Neuroprotective Effects of Oligosaccharides in Rehmanniae Radix on Transgenic Caenorhabditis elegans Models for Alzheimer's Disease |
| Rose Essential Oil | 📋 | | | | 38688895 | A comprehensive assessment of the cholinergic-supporting and cognitive-enhancing effects of Rosa damascena Mill. (Damask rose) essential oil on scopolamine-induced amnestic rats |
| Roselle | 📋 | ✍ | ⛔ | | 32480228 | Hibiscus Sabdariffa L.: A Potent Natural Neuroprotective Agent for the Prevention of Streptozotocin-Induced Alzheimer's Disease in Mice |
| Safflower | 📋 | ✍ | ⛔ | | 35940347 | Preventive effects of a standardized flavonoid extract of safflower in rotenone-induced Parkinson's disease rat model |
| Serrapeptase | 📋 | ✍ | ⛔ | | 35694981 | The potential of lumbrokinase and serratiopeptidase for the degradation of Aβ 1-42 peptide - an in vitro and in silico approach |
| Sesamin | 📋 | ✍ | | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Sesamol | 📋 | | | | 34669408 | Sesamol Attenuates Amyloid Peptide Accumulation and Cognitive Deficits in APP/PS1 Mice: The Mediating Role of the Gut-Brain Axis |
| Soy | 📋 | ✍ | ⛔ | | 37677911 | Different types of milk consumption and the risk of dementia: Analysis from a large-scale cohort study |
| Spices | 📋 | | | | 34279199 | Effects of Spices (Saffron, Rosemary, Cinnamon, Turmeric and Ginger) in Alzheimer's Disease |
| Strawberry | 📋 | ✍ | ⛔ | | 33547659 | Strawberry (Fragaria ananassa duch.) Alba extract attenuates DNA damage in lymphocytes of patients with Alzheimer's disease |
| Syringic Acid | 📋 | | | | 34599991 | Syringic acid demonstrates promising protective effect against tau fibrillization and cytotoxicity through regulation of endoplasmic reticulum stress-mediated pathway as a prelude to Alzheimer's disease |
| Tribulus Terrestris | 📋 | ✍ | ⛔ | | 33043200 | Anti-Parkinson's Activity of Tribulus terrestris via Modulation of AChE, α-Synuclein, TNF-α, and IL-1β |
| UDCA | 📋 | ✍ | ⛔ | | 38024855 | Protective effects of dioscin against Parkinson's disease via regulating bile acid metabolism through remodeling gut microbiome/GLP-1 signaling |
| Vitamin B7 | 📋 | ✍ | ⛔ | | 38045419 | Biotin rescues manganese-induced Parkinson's disease phenotypes and neurotoxicity |
| Vitexin | 📋 | | | | 37102042 | Beneficial Role of Vitexin in Parkinson's Disease |
| Wine | 📋 | | ⛔ | | 35326316 | Association of Alcohol Types, Coffee, and Tea Intake with Risk of Dementia: Prospective Cohort Study of UK Biobank Participants |
| Withaferin A | 📋 | | | | 34204308 | Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives |
| Almond | 📋 | | ⛔ | | 29208493 | Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer's disease: A neuropharmacological review of their bioactive constituents |
| Aloe-Emodin | 📋 | | | | 25453793 | Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and Hâ‚‚Oâ‚‚-induced cytotoxicity in PC12 cells |
| Aloin | 📋 | | | | 35421539 | Structural and mechanistic insights into modulation of α-Synuclein fibril formation by aloin and emodin |
| Alpha GPC | 📋 | ✍ | ⛔ | | 38595916 | Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease |
| Anthocyanidins | 📋 | | | | 31847371 | Association of Strawberries and Anthocyanidin Intake with Alzheimer's Dementia Risk |
| Apple | 📋 | | ⛔ | | 26298312 | Effects of an Antioxidant Beverage on Biomarkers of Oxidative Stress in Alzheimer's Patients |
| Apricot | 📋 | | ⛔ | | 36212969 | Pharmacological Potential of the Standardized Methanolic Extract of Prunus armeniaca L. in the Haloperidol-Induced Parkinsonism Rat Model |
| Astragalin | 📋 | | | | 36681681 | Neuroprotective effect of astragalin via activating PI3K/Akt-mTOR-mediated autophagy on APP/PS1 mice |
| Bamboo | 📋 | ✍ | ⛔ | | 38334213 | The alleviative effects comparison of four flavonoids from bamboo leaves on ulcerative colitis in an Alzheimer mouse model |
| Basil Essential Oil | 📋 | ✍ | ⛔ | | 29356981 | Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus |
| Beets | 📋 | ✍ | ⛔ | | 33054666 | Beetroot supplemented diet exhibit anti-amnesic effect via modulation of cholinesterases, purinergic enzymes, monoamine oxidase and attenuation of redox imbalance in the brain of scopolamine treated male rats |
| Beta-Cryptoxanthin | 📋 | | | | 35508396 | Association of Serum Antioxidant Vitamins and Carotenoids With Incident Alzheimer Disease and All-Cause Dementia Among US Adults |
| Beta-Glucan | 📋 | ✍ | ⛔ | | 36890624 | β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites |
| Beta-Lapachone | 📋 | | | | 30739428 | Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson's Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways |
| Biochanin A | 📋 | | | | 35338989 | Biochanin A alleviates cognitive impairment and hippocampal mitochondrial damage in ovariectomized APP/PS1 mice |
| Bitter Melon | 📋 | ✍ | ⛔ | | 36902074 | The Effects of Momordica charantia on Type 2 Diabetes Mellitus and Alzheimer's Disease |
| Black Ginger | 📋 | ✍ | ⛔ | | 36904098 | Kaempferia parviflora Extracts Protect Neural Stem Cells from Amyloid Peptide-Mediated Inflammation in Co-Culture Model with Microglia |
| Calcium | 📋 | ✍ | ⛔ | | 36478774 | Dietary calcium and magnesium intake and risk for incident dementia: The Shanghai Aging Study |
| Cardamom | 📋 | ✍ | ⛔ | | 31114535 | Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats |
| Cardamonin | 📋 | | | | 36672126 | The Neuroprotective Effects and Therapeutic Potential of the Chalcone Cardamonin for Alzheimer's Disease |
| Cashew | 📋 | | ⛔ | | 34576912 | Cashew Nut Shell Liquid (CNSL) as a Source of Drugs for Alzheimer's Disease |
| Cat's Claw | 📋 | ✍ | ⛔ | | 17294693 | Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40) |
| Cedarwood Essential Oil | 📋 | ✍ | ⛔ | | 32037737 | Examination of the influence of cedar fragrance on cognitive function and behavioral and psychological symptoms of dementia in Alzheimer type dementia |
| Chamomile | 📋 | ✍ | ⛔ | | 33824100 | Effect of M. chamomilla L. tea on chlorpromazine induced catalepsy: A neuroprotective study |
| Chamomile Essential Oil | 📋 | ✍ | ⛔ | | 38229887 | Biochemical characterization of chamomile essential oil: Antioxidant, antibacterial, anticancer and neuroprotective activity and potential treatment for Alzheimer's disease |
| Chebulinic Acid | 📋 | | | | 37453379 | Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses |
| Chlorella | 📋 | ✍ | ⛔ | | 37144207 | Exploring the therapeutic efficacy of Chlorella pyrenoidosa peptides in ameliorating Alzheimer's disease |
| Cinnamon Essential Oil | 📋 | ✍ | ⛔ | | 32166553 | Protective effects of Cinnamomum verum, Cinnamomum cassia and cinnamaldehyde against 6-OHDA-induced apoptosis in PC12 cells |
| Clove Essential Oil | 📋 | | ⛔ | | 37119836 | Swimming exercise and clove oil can improve memory by molecular responses modification and reduce dark cells in rat model of Alzheimer's disease |
| Corn Silk | 📋 | ✍ | ⛔ | | 37563784 | Role of corn silk for the treatment of Alzheimer's disease: A mechanism research based on network pharmacology combined with molecular docking and experimental validation |
| Dandelion | 📋 | ✍ | ⛔ | | 35053874 | Herbal Mixture of Carthamus tinctorius L. Seed and Taraxacum coreanum Attenuates Amyloid Beta-Induced Cognitive Dysfunction In Vivo |
| Dihydroartemisinin | 📋 | | | | 32210783 | Dihydroartemisinin Ameliorates Learning and Memory in Alzheimer's Disease Through Promoting Autophagosome-Lysosome Fusion and Autolysosomal Degradation for Aβ Clearance |
| Docosapentaenoic Acid | 📋 | ✍ | | | 33178186 | The Novel Omega-6 Fatty Acid Docosapentaenoic Acid Positively Modulates Brain Innate Immune Response for Resolving Neuroinflammation at Early and Late Stages of Humanized APOE-Based Alzheimer's Disease Models |
| Eclipta Alba | 📋 | ✍ | | | 33145730 | Neuroprotective effects of hydro-alcoholic extract of Eclipta alba against 1-methyl-4-phenylpyridinium-induced in vitro and in vivo models of Parkinson's disease |
| Elderberry | 📋 | ✍ | ⛔ | | 28214539 | Lumbee traditional medicine: Neuroprotective activities of medicinal plants used to treat Parkinson's disease-related symptoms |
| Eleuthero | 📋 | ✍ | ⛔ | | 38545117 | Acanthopanax senticosus improves cognitive impairment in Alzheimer's disease by promoting the phosphorylation of the MAPK signaling pathway |
| Equol | 📋 | ✍ | ⛔ | | 32761299 | Equol, a Blood-Brain Barrier Permeable Gut Microbial Metabolite of Dietary Isoflavone Daidzein, Exhibits Neuroprotective Effects against Neurotoxins Induced Toxicity in Human Neuroblastoma SH-SY5Y Cells and Caenorhabditis elegans |
| Escin | 📋 | ✍ | ⛔ | | 24657313 | Escin attenuates behavioral impairments, oxidative stress and inflammation in a chronic MPTP/probenecid mouse model of Parkinson's disease |
| Eucalyptus | 📋 | ✍ | ⛔ | | 35298858 | Effects of a moisturizer containing pseudo-ceramide and a eucalyptus extract on sweating function in adult atopic dermatitis: a double-blind, randomized, controlled left-right comparison clinical trial |
| Eucommia | 📋 | ✍ | ⛔ | | 35754707 | Eucommia ulmoides Olive Male Flower Extracts Ameliorate Alzheimer's Disease-Like Pathology in Zebrafish via Regulating Autophagy, Acetylcholinesterase, and the Dopamine Transporter |
| Fig | 📋 | | ⛔ | | 24938828 | Consumption of fig fruits grown in Oman can improve memory, anxiety, and learning skills in a transgenic mice model of Alzheimer's disease |
| Fish | 📋 | | ⛔ | | 33386799 | Association Between Dietary Fish and PUFA Intake in Midlife and Dementia in Later Life: The JPHC Saku Mental Health Study |
| Fufang Danshen | 📋 | | | | 29770796 | Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease |
| GABA | 📋 | ✍ | ⛔ | | 36734072 | The molecular mechanism of γ-aminobutyric acid against AD: the role of CEBPα/circAPLP2/miR-671-5p in regulating CNTN1/2 expression |
| Ginkgetin | 📋 | | | | 29214278 | Ginkgetin Ameliorates Neuropathological Changes in APP/PS1 Transgenical Mice Model |
| Ginkgolic Acid | 📋 | | | | 31654699 | Ginkgolic acid promotes autophagy-dependent clearance of intracellular alpha-synuclein aggregates |
| Glycyrrhetinic Acid | 📋 | | | | 37436491 | 18β-glycyrrhetinic acid ameliorates MPTP-induced neurotoxicity in mice through activation of microglial anti-inflammatory phenotype |
| Glycyrrhizic Acid | 📋 | ✍ | ⛔ | | 35358621 | Co-treatment with natural HMGB1 inhibitor Glycyrrhizin exerts neuroprotection and reverses Parkinson's disease like pathology in Zebrafish |
| Grape Seed Oil | 📋 | | ⛔ | | 32665902 | Grape Seed Oil as a Natural Therapy in Male Rats with Alzheimer's Diseases |
| Guggulsterone | 📋 | | | | 35714682 | Z-Guggulsterone attenuates cognitive defects and decreases neuroinflammation in APPswe/PS1dE9 mice through inhibiting the TLR4 signaling pathway |
| HMB | 📋 | ✍ | ⛔ | | 37437568 | Muscle-building supplement β-hydroxy β-methylbutyrate binds to PPARα to improve hippocampal functions in mice |
| Honey | 📋 | ✍ | ⛔ | | 37570596 | Apitherapy in Post-Ischemic Brain Neurodegeneration of Alzheimer's Disease Proteinopathy: Focus on Honey and Its Flavonoids and Phenolic Acids |
| Horny Goat Weed | 📋 | ✍ | ⛔ | | 36051307 | Molecular mechanism of Epimedium in the treatment of vascular dementia based on network pharmacology and molecular docking |
| Hypericin | 📋 | | | | 37183545 | Hypericin as a potential drug for treating Alzheimer's disease and type 2 diabetes with a view to drug repositioning |
| Isoflavones | 📋 | ✍ | ⛔ | | 34751296 | Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models |
| Isoquercitrin | 📋 | | | | 34047315 | The neuroprotective effects of isoquercitrin purified from apple pomace by high-speed countercurrent chromatography in the MPTP acute mouse model of Parkinson's disease |
| Isorhamnetin | 📋 | | | | 36160711 | Isorhamnetin Attenuated the Release of Interleukin-6 from β-Amyloid-Activated Microglia and Mitigated Interleukin-6-Mediated Neurotoxicity |
| Jujube | 📋 | | ⛔ | | 35922734 | An aqueous macerate of Ziziphus jujuba reduces long-term spatial memory impairment in D-galactose treated rats: role of anti-inflammatory pathways |
| Knotweed | 📋 | ✍ | ⛔ | | 25856718 | Ameliorative effects of physcion 8-O-β-glucopyranoside isolated from Polygonum cuspidatum on learning and memory in dementia rats induced by Aβ1-40 |
| Krill Oil | 📋 | ✍ | ⛔ | | 36185487 | Antarctic krill oil exhibited synergistic effects with nobiletin and theanine in ameliorating memory and cognitive deficiency in SAMP8 mice: Applying the perspective of the sea-land combination to retard brain aging |
| L-Citrulline | 📋 | ✍ | ⛔ | | 33940559 | Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease |
| L-Glutamine | 📋 | ✍ | ⛔ | | 38489176 | Mendelian Randomization of Blood Metabolites Suggests Circulating Glutamine Protects Against Late-Onset Alzheimer's Disease |
| L-Lysine | 📋 | ✍ | ⛔ | | 21127688 | Could Lysine Supplementation Prevent Alzheimer's Dementia? A Novel Hypothesis |
| L-Methionine | 📋 | ✍ | ⛔ | | 34573099 | L-Methionine Protects against Oxidative Stress and Mitochondrial Dysfunction in an In Vitro Model of Parkinson's Disease |
| L-Tryptophan | 📋 | ✍ | ⛔ | | 34105899 | Tryptophan in the diet ameliorates motor deficits in a rotenone-induced rat Parkinson's disease model via activating the aromatic hydrocarbon receptor pathway |
| Lactobacillus plantarum | 📋 | | ⛔ | | 27144579 | Effects of Lactobacillus plantarum TWK10-Fermented Soymilk on Deoxycorticosterone Acetate-Salt-Induced Hypertension and Associated Dementia in Rats |
| Lemon Balm Essential Oil | 📋 | ✍ | ⛔ | | 12143909 | Aromatherapy as a safe and effective treatment for the management of agitation in severe dementia: the results of a double-blind, placebo-controlled trial with Melissa |
| Lemon Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Lettuce | 📋 | | ⛔ | | 35101010 | In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa |
| Limonin | 📋 | | | | 37536186 | Oral administration of Limonin (LM) exerts neuroprotective effects by inhibiting neuron autophagy and microglial activation in 6-OHDA-injected rats |
| Lupeol | 📋 | | | | 37447385 | A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer's Disease |
| Madecassoside | 📋 | | | | 32721993 | Combining In Silico and In Vitro Studies to Evaluate the Acetylcholinesterase Inhibitory Profile of Different Accessions and the Biomarker Triterpenes of Centella asiatica |
| Malvidin | 📋 | | | | 35874261 | Antiamnesic Potential of Malvidin on Aluminum Chloride Activated by the Free Radical Scavenging Property |
| Mandarin | 📋 | | | | 33808343 | A Flavonoid-Rich Extract of Mandarin Juice Counteracts 6-OHDA-Induced Oxidative Stress in SH-SY5Y Cells and Modulates Parkinson-Related Genes |
| Minerals | 📋 | | | | 37509049 | What Dietary Vitamins and Minerals Might Be Protective against Parkinson's Disease? |
| Mustard | 📋 | | ⛔ | | 34856751 | Anti-Parkinson's evaluation of Brassica juncea leaf extract and underlying mechanism of its phytochemicals |
| Myrtle | 📋 | ✍ | ⛔ | | 30553998 | Evaluation of the protective effect of Myrtus communis in scopolamine-induced Alzheimer model through cholinergic receptors |
| Oats | 📋 | | ⛔ | | 34684684 | Oat Extract Avenanthramide-C Reverses Hippocampal Long-Term Potentiation Decline in Tg2576 Mice |
| Okra | 📋 | | ⛔ | | 37358589 | Abelmoschus esculentus (Okra) Prevents Insulin Resistance and Restores Neuron Autophagy by Regulating Dipeptidyl Peptidase-4 and Thus Improving Hippocampal Function |
| Oleanolic Acid | 📋 | | | | 35218459 | Ursolic acid and its isomer oleanolic acid are responsible for the anti-dementia effects of Ocimum sanctum in olfactory bulbectomized mice |
| Oolong Tea | 📋 | | ⛔ | | 35629970 | Metabolomics Study Suggests the Mechanism of Different Types of Tieguanyin (Oolong) Tea in Alleviating Alzheimer's Disease in APP/PS1 Transgenic Mice |
| Orange | 📋 | | ⛔ | | 36678510 | Characterization of Orange Peel Extract and Its Potential Protective Effect against Aluminum Chloride-Induced Alzheimer's Disease |
| Orange Essential Oil | 📋 | ✍ | ⛔ | | 33052945 | Aromatherapy improves cognitive dysfunction in senescence-accelerated mouse prone 8 by reducing the level of amyloid beta and tau phosphorylation |
| Pantethine | 📋 | ✍ | ⛔ | | 37194410 | Pantethine ameliorates recognition impairment in a mouse model of Alzheimer's disease by modulating cholesterol content and intestinal flora species |
| Parsnip | 📋 | | ⛔ | | 32700246 | Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study |
| Pau d'Arco | 📋 | ✍ | ⛔ | | 35240121 | Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates |
| Peppermint | 📋 | ✍ | ⛔ | | 38625964 | Neuroprotective potential of Mentha piperita extract prevents motor dysfunctions in mouse model of Parkinson's disease through anti-oxidant capacities |
| Peppermint Essential Oil | 📋 | ✍ | ⛔ | | 36986277 | Rosmarinus officinalis and Mentha piperita Oils Supplementation Enhances Memory in a Rat Model of Scopolamine-Induced Alzheimer's Disease-like Condition |
| Phloretin | 📋 | | | | 36463449 | Neuroprotective Effect of Phloretin in Rotenone-Induced Mice Model of Parkinson's Disease: Modulating mTOR-NRF2-p62 Mediated Autophagy-Oxidative Stress Crosstalk |
| Phosphatidylserine | 📋 | ✍ | ⛔ | | 33163896 | Effects of a Nutritional Formulation Containing Caprylic and Capric Acid, Phosphatidylserine, and Docosahexaenoic Acid in Streptozotocin-Lesioned Rats |
| Pine Needle Essential Oil | 📋 | ✍ | ⛔ | | 33655878 | Conifer Essential Oils Reversed Amyloid Beta1-42 Action by Modulating BDNF and ARC Expression in The Rat Hippocampus |
| Pine Nut | 📋 | | ⛔ | | 37821052 | Ameliorative effects of pine nut peptide-zinc chelate (Korean pine) on a mouse model of Alzheimer's disease |
| Pistachio | 📋 | ✍ | ⛔ | | 32529399 | Amelioration of motor and non-motor deficits and increased striatal APoE levels highlight the beneficial role of pistachio supplementation in rotenone-induced rat model of PD |
| Polydatin | 📋 | ✍ | | | 22483554 | Polydatin protects learning and memory impairments in a rat model of vascular dementia |
| Postbiotics | 📋 | | | | 37934614 | Gut microbiome-targeted therapies for Alzheimer's disease |
| Pregnenolone | 📋 | ✍ | ⛔ | | 36878398 | Pregnenolone for the treatment of L-DOPA-induced dyskinesia in Parkinson's disease |
| Protein | 📋 | ✍ | ⛔ | | 38674911 | Analysis of the Association between Protein Intake and Disability-Adjusted Life Year Rates for Alzheimer's Disease in Japanese Aged over 60 |
| PUFA | 📋 | | | | 37046127 | Circulating polyunsaturated fatty acids, fish oil supplementation, and risk of incident dementia: a prospective cohort study of 440,750 participants |
| Pumpkin Seed | 📋 | ✍ | ⛔ | | 33759084 | Antiparkinsonian activity of Cucurbita pepo seeds along with possible underlying mechanism |
| Pyridoxal-5-Phosphate | 📋 | ✍ | ⛔ | | 31987026 | An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice |
| Raspberry | 📋 | ✍ | ⛔ | | 26773014 | Red Raspberries and Their Bioactive Polyphenols: Cardiometabolic and Neuronal Health Links |
| Rosavin | 📋 | | ⛔ | | 37758932 | Rosavin thwarts amyloid-β-induced macromolecular damages and neurotoxicity, exhibiting anti-Alzheimer's disease activity in Wister rat model |
| Rose | 📋 | | | | 37078068 | Effect of Rosa damascena Extract on Rat Model Alzheimer's Disease: A Histopathological, Behavioral, Enzyme Activities, and Oxidative Stress Study |
| Rosehip | 📋 | ✍ | ⛔ | | 27563424 | Neuroprotective Effects of Herbal Extract (Rosa canina, Tanacetum vulgare and Urtica dioica) on Rat Model of Sporadic Alzheimer's Disease |
| Safranal | 📋 | | | | 38683404 | Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation |
| SAMe | 📋 | ✍ | ⛔ | | 32597804 | S-Adenosylmethionine Alleviates Amyloid-β-Induced Neural Injury by Enhancing Trans-Sulfuration Pathway Activity in Astrocytes |
| Scutellarein | 📋 | | | | 37239029 | A Multilevel Study of Eupatorin and Scutellarein as Anti-Amyloid Agents in Alzheimer's Disease |
| Scutellarin | 📋 | | | | 35964195 | Scutellarin Modulates the Microbiota-Gut-Brain Axis and Improves Cognitive Impairment in APP/PS1 Mice |
| Sea Buckthorn | 📋 | ✍ | ⛔ | | 37132070 | Polysaccharides from sea buckthorn (Hippophae rhamnoides L.) berries ameliorates cognitive dysfunction in AD mice induced by a combination of D-gal and AlCl3 by suppressing oxidative stress and inflammation reaction |
| Seafood | 📋 | | | | 36354985 | Marine Sources of DHA-Rich Phospholipids with Anti-Alzheimer Effect |
| Seaweeds | 📋 | | ⛔ | | 36662216 | Application of Marine Natural Products against Alzheimer's Disease: Past, Present and Future |
| Sesame | 📋 | ✍ | ⛔ | | 37539928 | Neuroprotective effects of Sesamum indicum, sesamin and sesamolin against 6-OHDA-induced apoptosis in PC12 cells |
| Sesame Oil | 📋 | | ⛔ | | 33049345 | Sesame oil mitigates memory impairment, oxidative stress, and neurodegeneration in a rat model of Alzheimer's disease. A pivotal role of NF-κB/p38MAPK/BDNF/PPAR-γ pathways |
| Shilajit | 📋 | ✍ | ⛔ | | 37513872 | Scaling the Andean Shilajit: A Novel Neuroprotective Agent for Alzheimer's Disease |
| Shogaol | 📋 | | | | 37337830 | 6-Shogaol, an Active Ingredient of Ginger, Improves Intestinal and Brain Abnormalities in Proteus Mirabilis-Induced Parkinson's Disease Mouse Model |
| Sorghum | 📋 | | ⛔ | | 34690742 | Potential of Sorghum Polyphenols to Prevent and Treat Alzheimer's Disease: A Review Article |
| Soy Protein | 📋 | ✍ | ⛔ | | 36561237 | Ameliorating Effect of Standardized Extract From Textured Soy Protein ( Glycine max L.) on Memory Deficit and Learning Insufficiency in Scopolamine-induced Amnesia |
| Spearmint Essential Oil | 📋 | ✍ | ⛔ | | 31772594 | Biological Properties and Bioactive Components of Mentha spicata L. Essential Oil: Focus on Potential Benefits in the Treatment of Obesity, Alzheimer's Disease, Dermatophytosis, and Drug-Resistant Infections |
| Star Fuit | 📋 | | ⛔ | | 30196278 | Protective Effects of 2-Dodecyl-6-Methoxycyclohexa-2,5 -Diene-1,4-Dione Isolated from Averrhoa Carambola L. (Oxalidaceae) Roots on Neuron Apoptosis and Memory Deficits in Alzheimer's Disease |
| Sweet Potato | 📋 | | ⛔ | | 35720655 | Effect of providing purple sweet potato water extract on tumor necrosis factor-α levels, protein 53 expression, glial fibrillary acidic protein expression, brain-derived neurotrophic factor levels, and spatial working memory in rats with d-galactose induction |
| Tamarind | 📋 | | ⛔ | | 35481086 | The anti-Alzheimer potential of Tamarindus indica: an in vivo investigation supported by in vitro and in silico approaches |
| Theaflavins | 📋 | ✍ | | | 22138428 | Theaflavin, a black tea polyphenol, protects nigral dopaminergic neurons against chronic MPTP/probenecid induced Parkinson's disease |
| Theobromine | 📋 | ✍ | ⛔ | | 27792010 | Theobromine-Induced Changes in A1 Purinergic Receptor Gene Expression and Distribution in a Rat Brain Alzheimer's Disease Model |
| Thyme Essential Oil | 📋 | | ⛔ | | 38688382 | Investigating the effects of Thymus vulgaris essential oil, Allium cepa extract, and their active compounds (thymol and quercetin) on expression profile of genes related to Alzheimer's disease in PC12 model cell |
| Trans-Resveratrol | 📋 | | | | 34402024 | Neuroprotective Effect of Trans-Resveratrol in Mild to Moderate Alzheimer Disease: A Randomized, Double-Blind Trial |
| Turkey Tail Mushrooms | 📋 | | ⛔ | | 36289766 | Natural Compounds Such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson's Disease in Mice |
| Vitamin B Complex | 📋 | | ⛔ | | 35714552 | The role of mixed B vitamin intakes on cognitive performance: Modeling, genes and miRNAs involved |
| Vitamin B2 | 📋 | ✍ | ⛔ | | 28775706 | Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine |
| Vitamin K | 📋 | ✍ | ⛔ | | 35475263 | Association of vitamin K with cognitive decline and neuropathology in community-dwelling older persons |
| Vitamin K2 mk-7 | 📋 | ✍ | | | 37477796 | Vitamin K2 protects against aluminium chloride-mediated neurodegeneration |
| Vitex | 📋 | ✍ | ⛔ | | 35023027 | Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol induced parkinson's disease in rat |
| Whey Protein | 📋 | ✍ | ⛔ | | 37414601 | Whey protein powder with milk fat globule membrane attenuates Alzheimer's disease pathology in 3×Tg-AD mice by modulating neuroinflammation through the peroxisome proliferator-activated receptor γ signaling pathway |
| White Mushrooms | 📋 | | ⛔ | | 36291298 | White Button Mushroom ( Agaricus bisporus) Supplementation Ameliorates Spatial Memory Deficits and Plaque Formation in an Amyloid Precursor Protein Mouse Model of Alzheimer's Disease |
| Xylitol | 📋 | ✍ | ⛔ | | 36154609 | Dietary xylitol supplement ameliorated AD related neuronal injury by regulating glucose metabolism relevant amino acids in mice |
